早期生活中甲酸盐和替代性增塑剂的暴露以及早期儿童大脑功能连接和结构形态的变化
Stephanie M Engel1, Tengfei Li2, Emily J Werder3
1Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Environment international
|February 11, 2026
概括
早期暴露于酸盐和替代性增塑剂 (PRPs) 影响大脑发育. 男孩显示功能连接性下降,而女孩显示增加连接性和皮质稀释与PRP暴露.
科学领域:
- 神经科学是一个神经科学.
- 环境健康 环境健康
- 发展生物学 发展生物学
背景情况:
- 酸盐和替代性增塑剂 (PRP) 是常见的环境暴露物.
- 产前和儿童早期接触PRP与认知和行为发展问题有关.
- 在关键发育时期对大脑结构和功能的潜在影响尚未完全理解.
研究的目的:
- 调查早期接触PRP与儿童大脑发育之间的关联.
- 检查对静态网络的功能连接和皮质区域的结构形态学的影响.
- 在这些关联中识别性别特异性差异.
主要方法:
- 对2周至5岁的儿童进行长度研究 (婴儿连接组项目).
- 在自然睡眠期间获得非镇静的结构性和休息状态的功能性MRI.
- 用核加权估计方程和通用线性模型对17种PRP代谢物的尿样进行分析.
主要成果:
- 多个PRP代谢物与执行控制和背部注意网络的功能连接性发生变化有关.
- 暴露PRP与男孩的功能连接性下降和女孩的连接性增加有关.
- 女孩的MiBP代谢物度与叶区域的皮质稀释有关.
结论:
- 早期的PRP暴露对大脑成熟轨迹有可衡量的影响.
- 在PRP暴露对大脑发育的影响方面存在显著的性别差异.
- 这些发现凸显了早期发育期间环境暴露的重要性.
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