母亲和父亲对原油的暴露不同地塑造了大西洋鱼 (Gadus morhua) 的早期发育转录组和生存结果
Claudia Erhart1, Jasmine Nahrgang1, Derrick Kwame Odei1
1Department of Arctic and Marine Biology, UiT The Arctic University of Norway, 9037, Tromsø, Norway.
Marine pollution bulletin
|February 11, 2026
概括
孕产妇接触原油严重影响大西洋鱼 (Gadus morhua) 后代的生存和发育,因为它破坏了卵子的质量. 父亲暴露显示出延迟的,次致命的效果,突出显示了代际风险.
科学领域:
- 海洋生物学 海洋生物学
- 生态毒理学 生态毒理学
- 基因组学就是基因组学.
背景情况:
- 大西洋鱼 (Gadus morhua) 的可持续性受到原油污染的威胁.
- 成人的生殖脆弱性和石油暴露的代际影响尚不清楚.
- 父亲对后代结果的贡献需要进一步调查.
研究的目的:
- 调查父母接触原油对大西洋鱼后代的影响.
- 分析转录组特征和后代的存活率.
- 为了评估原油效应的母亲和父亲的转移.
主要方法:
- 成年大西洋鱼暴露于原油.
- 后代是通过体外受精 (对照,母,父,双亲暴露) 生产的.
- 分析了转录形状,心脏功能,形态和生存率.
主要成果:
- 孕产妇暴露导致后代在化之前死亡,卵子尺寸更小,以及下调发育基因.
- 石油芳香碳化合物被转移到卵细胞中,表明卵细胞供应被破坏.
- 父亲暴露对化时的RNA表达和形态学产生了很小的影响,但表明了以后的亚致命效应.
结论:
- 孕产妇接触原油严重影响大西洋鱼的早期发育.
- 卵细胞成熟期间的内分泌和表观遗传障碍可能会导致发育问题.
- 父亲暴露可能会诱导延迟的,可能通过表观遗传机制的次致命效应,这需要进一步研究.
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