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赫斯佩雷丁在佐勒龙酸和炎症性压力下调节骨质生殖细胞和巨细胞

Igor Paulino Mendes Soares¹, Owen Liepman², Caroline Anselmi²

¹Department of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, USA; Department of Dental Materials and Prosthodontics, São Paulo State University (UNESP), School of Dentistry, Araraquara, Brazil.

Archives of oral biology

|February 11, 2026

概括

赫斯佩雷丁 (HT) 通过增强骨质分化和抑制介质干细胞和巨细胞的炎症来促进骨再生. 这种天然化合物显示出治疗与双酸盐相关的骨髓缩的潜力.

科学领域:

生物材料科学生物材料科学
干细胞生物学干细胞生物学
免疫学免疫学免疫学

背景情况:

双酸盐,就像龙酸 (ZA) 一样,对于治疗骨疾病至关重要,但可以导致骨衰竭.
介酶干细胞 (MSC) 和巨细胞在骨修复和免疫反应中起着至关重要的作用.
赫斯佩雷丁 (HT) 是一种黄类化合物,具有抗炎和抗氧化特性.

研究的目的:

为了研究hesperetin (HT) 对膜骨衍生介质干细胞 (aBMSCs) 和巨细胞的骨质原生和免疫调节作用.
为了评估HT在模仿甲酸 (ZA) 暴露和炎症应激条件下的疗效.

主要方法:

aBMSCs被用ZA和/或HT治疗,细胞活力和骨质生成活性被评估.
来自THP-1的巨细胞被两极分化并用HT处理,以评估细胞因子的产生.
在HT治疗的炎症条件下建立了aBMSC和巨细胞的共培养.

主要成果:

佐勒多尼酸 (ZA) 降低了aBMSC的活力和矿化,HT部分恢复了这一点.
赫斯佩雷丁 (HT) 降低了M1巨细胞中促炎性细胞因子 (TNF-α,IL-1α,IL-6) 的产生.
在共同培养中,HT保持了细胞活力,增强了矿化基质的形成,并减少了细胞因子的释放.

结论:

赫斯佩雷丁 (HT) 具有双重作用,促进骨质生成和减少炎症.
HT是一种潜在的骨质免疫调节剂,可以增强骨再生.
通过改善骨愈合和减少炎症,HT可以减轻双酸盐相关的骨 necrosis.

关键词:

骨再生骨的再生共同种植技术共同种植技术黄类化合物黄类化合物免疫调节是一种免疫调节.佐勒多尼酸是一种酸.

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