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Updated: Feb 13, 2026

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
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一个综合框架确定了针对IRE1α的强效抑制剂

Subramaniyan Divya1, Priti Talwar2, Palaniyandi Ravanan1

  • 1Functional Genomics Laboratory, Department of Microbiology, School of Life Sciences, Central University of Tamil Nadu, Thiruvarur 610005, Tamil Nadu, India.

Bioorganic & medicinal chemistry
|February 11, 2026
PubMed
概括

黄胺素 (amentoflavone和glycitein) 抑制IRE1α激酶活性,调节未折叠蛋白响应 (UPR) 信号传递,为治疗ER压力和炎症性疾病提供潜力.

关键词:
黄类化合物 黄类化合物在 IRE1α 调节器.停靠后的接近方式.

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