精神分裂症中的距离和层次依赖的功能性失联性及其与皮质微观结构的关联
Isaac David1, Shuntaro Sasai2, Felipe Branco de Paiva2
1Department of Psychiatry, University of Wisconsin, Madison, WI, United States of America; Neuroscience Training Program, University of Wisconsin, Madison, WI, United States of America.
NeuroImage. Clinical
|February 11, 2026
概括
精神分裂症患者在感官区域的短距离功能连接性降低,这与微观结构变化有关. 在没有类似结构联系的其他大脑区域中,更远距离的连接增加.
科学领域:
- 神经科学是一个神经科学.
- 脑部成像 脑部成像
- 精神病学是一个精神病学.
背景情况:
- 精神分裂症与大脑广泛的功能性失联性有关.
- 这些变化的空间规模和结构基础尚未完全理解.
- 标准方法难以捕捉与局部功能障碍相关的短距离连接.
研究的目的:
- 调查精神分裂症中功能性失联的空间尺度和结构相关性.
- 应用功能连接强度 (FCS) 的距离依赖分析.
- 检查与功能变化相关的微观结构差异.
主要方法:
- 利用86名精神分裂症患者和99名对照者的静止状态fMRI数据的顶点智能,距离依赖分析.
- 按地理距离划分FCS并根据皮层层次结构分析.
- 评估T1/T2比率和个性化数据驱动功能连接密度 (idFCD) 作为微结构代理.
主要成果:
- 精神分裂症患者在背部主要体感皮质中显示出减少的短距离FCS,与微观结构异常共定位.
- 在跨模区域 (例如,precuneus) 观察到更长范围的FCS增加,没有相关的微观结构差异.
- 层次分析揭示了初级网络中的结构-功能中断,以及跨模式地区相对FCS的增加.
结论:
- 精神分裂症表现出明显的皮质失联模式:微观结构变化的初级感官区域的短程减少,以及跨模区域的长程增加.
- 这些发现凸显了主要地区短距离连接中断的作用.
- 这项研究通过将距离依赖的功能测量与微观结构数据相结合,为传统分析提供了一个补充框架.
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