在患有多发性硬化症的人群中,在同度收缩期间,力量控制和肌肉激活受损
Mélanie Henry1, Thomas Crompton1, Enrique Alvarez2
1Department of Integrative Physiology, University of Colorado Boulder, CO, USA.
概括
与健康个体相比,患有多发性硬化症 (MS) 的人在下腿肌肉中表现出受损的力量控制. 然而,这种运动障碍与自我报告相反,他们的腿之间并不不对称.
科学领域:
- 神经科学是一个神经科学.
- 康复医学 康复医学 康复医学
- 神经学 神经学
背景情况:
- 运动障碍,特别是不对称的障碍,对患有多发性硬化症 (MS) 的个体产生重大影响,影响该人口的高达80%.
- 自我报告经常表明肢体参与的差异,但需要客观的神经控制评估.
研究的目的:
- 调查MS患者在力量产生期间下腿肌肉神经控制中的不对称性.
- 为了比较MS患者中受影响较多和影响较少的腿部之间的力量控制和肌肉活动.
主要方法:
- 18名多发性硬化症患者和17名健康对照人进行了脊椎 flexor和足部 flexor肌肉的亚最大同位数收缩.
- 评估力量控制,包括测量精度和稳定性,以及下腿肌肉的电肌图 (EMG) 活动.
主要成果:
- 与健康对照组相比,患有多发性硬化症的个体在肢体和任务上表现出明显较差的力量控制 (p ≤ 0.003).
- 多发性硬化参与者表现出改变的肌肉激活模式,包括在脚部曲过程中增加的对手活性 (p ≤0.042) 和在背部曲过程中增加的对手活性和共同收缩 (p <0.001).
- 在MS组中,在受影响较多或较少的腿之间没有发现显著的性能或肌肉活动差异.
结论:
- 这项研究揭示了MS中下腿肌肉力量控制的普遍缺陷,无论肢体不对称.
- 研究结果表明,MS中神经控制的改变会影响整体肌肉功能,而不是局限于一个肢体.
- 这些结果可以为开发针对多发性硬化症中运动障碍的目标康复策略提供信息.
相关概念视频
01:22Isotonic and Isometric Muscle Contractions
7.4K
Two primary types of muscle contractions are isotonic and isometric, each serving unique functions and involving distinct mechanisms. Both isotonic and isometric contractions are integral to the body's complex system of movement and stability. Isotonic exercises contribute significantly to functional strength and movement, while isometric contractions are crucial for maintaining posture and joint stability.
Isotonic contractions
Isotonic contractions occur when a muscle changes length while...
Isotonic contractions
Isotonic contractions occur when a muscle changes length while...
7.4K
01:15Muscle Contraction
96.4K
96.4K
01:10Muscle Contraction
9.0K
In skeletal muscles, acetylcholine is released by nerve terminals at the motor endplate—the point of synaptic communication between motor neurons and muscle fibers. The binding of acetylcholine to its receptors on the sarcolemma allows entry of sodium ions into the cell and triggers an action potential in the muscle cell. Thus, electrical signals from the brain are transmitted to the muscle. Subsequently, the enzyme acetylcholinesterase breaks down acetylcholine to prevent excessive...
9.0K
01:25Smooth Muscle Contraction
8.0K
Smooth muscle contraction is a complex process vital for various bodily functions, from maintaining blood vessel tension to facilitating the movement of food through the digestive tract. Unlike striated muscles, smooth muscle contraction begins more slowly and lasts longer.
The onset of contraction is triggered by an increase in calcium ions within the sarcoplasm, similar to the process in striated muscle. However, smooth muscles have a relatively smaller reservoir of the sarcoplasmic...
The onset of contraction is triggered by an increase in calcium ions within the sarcoplasm, similar to the process in striated muscle. However, smooth muscles have a relatively smaller reservoir of the sarcoplasmic...
8.0K
01:25Energy Supply for Muscle Contraction
5.7K
Skeletal muscle fibers have the unique ability to switch between rest and contraction states, using different sources of ATP for energy. The contraction cycle and Ca2+ transport back into the sarcoplasmic reticulum for relaxation require significant ATP. However, the ATP reserves in muscle fibers are limited and can only sustain contractions for a few seconds. Additional ATP production becomes necessary for prolonged contractions. As a result, muscle fibers generate ATP through various sources,...
5.7K
01:16Actin and Myosin in Muscle Contraction
24.4K
Actin and myosin are contractile proteins that form the sarcomere found in skeletal muscle tissues for regulating muscle contraction. Actin, a globular contractile protein, interacts with myosin for muscle contraction. The skeletal tissue appears striped or striated under a microscope due to the repeated arrangement of contractile proteins actin and myosin along the length of myofibrils. Dark A bands and light I bands repeat along myofibrils, and the alignment of myofibrils in the cell causes...
24.4K