为了更安全,更环保的生物医学植入物,β-合金的进步
Dulexy Solano-Orrala1, Eliana Díaz-Cruces2, Jorge Troconis3
1Bioengineering & Regenerative Medicine Research Group (Bio-ReM), Escuela de Ingeniería, Arquitectura y Diseño (EIAD), Universidad Alfonso X el Sabio (UAX), Avenida de la Universidad 1, 28691, Villanueva de la Cañada, Madrid, Spain; Biomedical Research Unit (UIB-UAX), Universidad Alfonso X el Sabio (UAX), Avenida de la Universidad 1, 28691 Villanueva de la Cañada, Madrid, Spain.
新的β- (β-Ti) 合金正在开发用于生物医学应用,重点是安全性和可持续性. 本综述涵盖了合金设计,临床前证据和创建下一代骨科和牙科植入物的先进方法.
科学领域:
- 生物材料科学 生物材料科学
- 材料工程 材料工程 材料工程
- 整形外科和牙科植入物学
背景情况:
- 合金被广泛用于生物医学植入物,因为其生物相容性和强度.
- 对某些合金元素 (如,,铜) 的潜在细胞毒性存在担忧.
- 需要具有较低弹性模量,改善骨兼容性和排除有毒元素的合金.
研究的目的:
- 通过使用更安全,更环保的方法,审查β- (β-Ti) 合金设计的最新进展.
- 强调临床前的体外和体内研究,以评估安全性和性能.
- 讨论人工智能和计算方法在合金优化中的作用.
主要方法:
- 综合性文献综述,重点关注β-Ti合金的设计和加工.
- 临床前安全性和性能数据的分析 (体外和体内).
- 包括监管,知识产权,生命周期和可持续性评估.
主要成果:
- 突出了开发更安全,更环保的β-Ti合金方面的进展.
- 整合合金设计,加工,临床前证据和可持续性.
- 讨论了人工智能和机器学习在预测和优化合金特性方面的潜力.
结论:
- 为更安全,更绿色的植入物提供临床翻译的框架.
- 将β-Ti合金开发与循环经济和可生物降解替代品联系起来.
- 提供了影响未来合金植入物开发的因素的整体概述.
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