来自酵母和乳酸细菌的生物纳米颗粒的抗癌潜力:进展,挑战和机遇
G M Rodríguez-Serrano1, M Párraga-San Roman2, C E Jara-Gutiérrez2
1Departamento de Biotecnología, Universidad Autónoma Metropolitana, Unidad Iztapalapa, Ciudad de México AP 55-355, México.
概括
微生物纳米粒子 (SeNPs) 由于其环保合成和选择性抗癌作用,对癌症治疗具有前景. 需要进一步的研究来规范生产并确认治疗效益.
科学领域:
- 纳米医学是一种纳米医学.
- 生物技术是生物技术.
- 材料科学 材料科学 材料科学
背景情况:
- 微生物生物纳米粒子 (SeNPs) 正在成为纳米医学中宝贵的工具.
- 它们的环保合成和固有的抗癌特性使它们对治疗开发具有吸引力.
研究的目的:
- 用酵母和乳酸细菌审查SeNPs的合成.
- 探索它们的物理化学特性,抗癌机制和癌症治疗中的治疗潜力.
主要方法:
- 在主要的科学数据库 (PubMed,Scopus,Web of Science,ScienceDirect) 进行系统的文献搜索.
- 包括2010-2025年的研究,重点关注微生物SeNP合成和生物医学应用.
- 对108篇选定的文章进行主题分析,涵盖合成,表征,机制和应用.
主要成果:
- 酵母和细菌是SeNP生物合成的有效微生物剂,产生稳定和生物相容的纳米粒子.
- 像大小和形状这样的SeNP特性会影响生物活动,诱导癌细胞亡和DNA损伤.
- 微生物SeNPs对癌细胞具有选择性毒性,对健康组织的影响较小,功能化提高了它们的治疗性能.
结论:
- 微生物SeNPs是可持续的纳米材料,在抗癌研究中具有重大潜力.
- 挑战包括扩大生产规模,标准化合成,并进行进一步的临床评估.
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