基于炎症的指数与急性深静脉血栓和血栓负担之间的关联
Yifei Bai1, Da Li2, Xin Huang2
1Department of Interventional and Vascular Surgery, The Third Affiliated Hospital of Nanjing Medical University (Changzhou Second People's Hospital), Changzhou 213003, China.
Heart & lung : the journal of critical care
|February 11, 2026
概括
来自全血计数的炎症指数,如淋巴细胞对单细胞的比率 (LMR),可以帮助诊断深静脉血栓症 (DVT) 并评估血块大小. 这些标记物的高特异性有助于对DVT患者的风险分层.
科学领域:
- 血液学 血液学 血液学
- 血管医学 血管医学
- 诊断生物标志物 诊断生物标志物
背景情况:
- 炎症在静脉血栓形成中起着关键作用.
- 全血清 (CBC) 衍生的炎症指数正在成为潜在的生物标志物.
- 需要进一步的研究来确定它们在诊断急性深静脉血栓症 (DVT) 和评估血栓负担方面的有用性.
研究的目的:
- 评估CBC衍生的炎症指数对急性DVT的诊断和预后价值.
- 评估中性粒细胞与淋巴细胞的比率 (NLR),血小板与淋巴细胞的比率 (PLR),全身免疫炎症指数 (SII),淋巴细胞与单细胞的比率 (LMR) 和全身炎症反应指数 (SIRI).
主要方法:
- 360名接受静脉多普勒超声波的患者的回顾性分析.
- 患者被分为非DVT,隔离远距离DVT (IDDVT) 和近距离DVT (PDVT) 组.
- 用接收器操作特征 (ROC) 曲线分析和统计测试来评估预测能力和群体差异.
主要成果:
- 与对照组相比,患有急性DVT的患者表现出明显更高的NLR,PLR,SII和SIRI,以及较低的LMR.
- 最低残留量显示了急性DVT的最高预测疗效 (AUC:0.737) 具有85.5%的特异性.
- 在区分IDDVT和PDVT方面,NLR和LMR具有重要意义.
结论:
- NLR和LMR是诊断急性DVT和评估血栓负担的宝贵生物标志物.
- 它们的高特异性支持它们在风险分层中的使用.
- 然而,由于它们的敏感性较低,因此需要与全面的临床评估进行整合,以实现最佳的患者管理.
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