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在多发性硬化症中对外周血液氧化应激进行分析.
Thomas Minton1, Kelly Hares2, Kevin Kemp2
1Translational Health Sciences, Bristol Medical School, University of Bristol, United Kingdom; Department of Neurology, Southmead Hospital, North Bristol NHS Trust, Bristol, United Kingdom.
Multiple sclerosis and related disorders
|February 11, 2026
概括
氧化应激反应在多发性硬化症 (MS) 中发生变化. 虽然单个生物标志物对MS分层不有用,但组合可能会为MS病理生理学和治疗提供临床实用性和洞察力.
科学领域:
- 神经免疫学 神经免疫学
- 生物标志物发现发现
- 氧化压力研究研究 氧化压力研究
背景情况:
- 氧化应激与多发性硬化症 (MS) 病理生理学有关.
- 氧化应激反应作为MS生物标志物的实用性仍未得到充分研究.
研究的目的:
- 系统地研究氧化应激反应作为患有多发性硬化症 (pwMS) 患者的潜在生物标志物.
- 评估与MS亚型和疾病修饰疗法 (DMT) 相关的抗氧化调节剂和氧化产品的变化.
主要方法:
- 血和外周血液单核细胞 (PBMC) 氧化应激标志物的连续测量在12个月的pwMS和对照中.
- 分析包括抗氧化剂调节剂,酶和氧化终产物,并对临床因素进行多变量回归调整.
- 包括开始使用二甲基 fumarate (DMF),ocrelizumab或natalizumab的队列.
主要成果:
- 在二次进展性MS (SPMS) 中观察到的NFE2L2 (核因子红色素2相关因子2),CAT (catalase) 和GPX1 (glutathione peroxidase 1) 表达的下调.
- 在pWMS中增加的血过氧体增殖器激活受体马协激活剂1-α (PGC-1α); Nrf2,催化酶活性和SOD1表达增加了DMF.
- 纳塔利祖马布增加了PBMC NFE2L2,GPX1和SOD1的表达,但效果大小很小,异质性很高.
结论:
- 数据支持MS中氧化应激失调,但单个标志物不太可能分层或监测疾病.
- 氧化应激生物标志物的星座可能对了解多发性硬化病理生理学和指导治疗具有临床实用性.
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