通过消化酶去除,转化和毒性变化哈洛诺基
Liu He1, De-Xiu Wu1, Wen-Min Wang1
1Shenzhen Key Laboratory of Ecological Remediation and Carbon Sequestration, Environmental Protection Key Laboratory of Microorganism Application and Risk Control, Institute of Environment and Ecology, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, PR China; Key Laboratory of Microorganism Application and Risk Control of Shenzhen, Guangdong Provincial Engineering Research Center for Urban Water Recycling and Environmental Safety, Institute of Environment and Ecology, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, PR China.
消化酶显著地去除和转化有毒的青 (HBQs),减少它们的健康风险. 肠道消化是最有效的,但仍有一些毒性,影响饮用水安全评估.
科学领域:
- 环境化学环境化学
- 毒理学 毒理学 毒理学
- 生物化学 生物化学
背景情况:
- 青 (HBQs) 是有毒的消毒副产品,耐常规水处理.
- 它们在人类消化过程中的命运和转变在很大程度上是未知的.
- 了解胃肠道中的HBQ行为对于健康风险评估至关重要.
研究的目的:
- 为了研究由消化酶介导的HBQs的去除,转化和毒性变化.
- 阐明酶-HBQ相互作用的机制.
- 评估酶降解对HBQ毒性的影响.
主要方法:
- 模拟消化使用唾液氨酶,素和素.
- 酶结合亲和性研究和QM/MM模拟.
- 转化产品的分析和细胞毒性和基因毒性的评估,使用结肠器官样本测定.
主要成果:
- 模拟消化显著加速HBQ的去除,肠道消化显示最高的效率 (87.196.0%).
- 2,6-DCBQ对消化酶具有最强的结合亲和力.
- 酶作用转化了C=O键,与酶形成了共价添加物,通过产生较少的氧化应激产物,降低了HBQ细胞毒性和基因毒性.
结论:
- 消化酶在人体内HBQ的去除和转化中发挥着关键作用.
- 酶降解可以降低HBQ的毒性,但不能完全消除它.
- 这些发现为评估饮用水中HBQs相关的人体健康风险提供了关键的见解.
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