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Updated: Feb 13, 2026

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在TET2-突变的克隆性血液形成中,对先天免疫激活的代谢控制

Peter Geon Kim1, Christopher B Hergott2, Aidan P Miller3

  • 1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Cancer Center, Mass General Research Institute, Massachusetts General Hospital, Boston, MA, USA.

Cell chemical biology
|February 11, 2026
PubMed
概括

克隆性血液形成中的TET2损失通过破坏涉及O-GlcNAc糖系转移酶 (Ogt) 的代谢循环引发炎症. 这导致异常的染色质重塑和脂质积累,驱动髓状细胞免疫激活.

关键词:
这是一种Tet2-突变性炎症.克隆性血液形成 (clonal hematopoiesis) 是一种细胞形成的过程.造血干-原始人的选.脂质滴滴滴滴滴滴滴滴滴滴滴滴滴

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