一种实用方法来整合基于证据的医学和个性化医学:个性化微生物组向干预措施的例子
D Zeilstra1,2, A A Te Velde3, G Remmers4
1Nutriz, Deventer, the Netherlands.
Beneficial microbes
|February 11, 2026
概括
基于证据的个性化医学 (EBPM) 整合了基于证据的医学 (EBM) 和个性化医学 (PM) 以优化患者护理. 这种方法将患者数据与证据分级相结合,提供量身定制的治疗建议,增强临床决策.
科学领域:
- 医疗信息学 医疗信息学
- 临床决策支持 临床决策支持
- 基于证据的实践.
背景情况:
- 医疗保健从业人员 (HCP) 旨在提供最佳的患者护理,但定义"最佳"干预是复杂的.
- 基于证据的医学 (EBM) 和个性化医学 (PM) 提供了干预选择的框架,每个都有局限性.
- 整合EBM和PM可以通过利用两种范式的优势来加强临床决策.
研究的目的:
- 从患者和医疗保健专家的角度审查EBM和PM的优缺点.
- 探索整合EBM和PM的方法论和实践方面.
- 提出并举例说明一种实用方法,即基于证据的个性化医学 (EBPM),用于选择最佳干预措施.
主要方法:
- 对EBM和PM的优点和弱点进行文献综述.
- 在实用主义的世界观下整合EBM和PM的认识论分析.
- 开发和应用一个为微生物向干预的四步EBPM模型.
主要成果:
- 一种务实的方法 (EBPM) 可以结合EBM和PM的优势.
- 该EBPM模型整合了个体患者的数据,偏好和分级证据.
- 拟议的EBPM方法促进了个性化干预建议和反循环.
结论:
- 基于证据的个性化医学 (EBPM) 为优化干预选择提供了一个强大的框架.
- 通过个性化基于证据的建议,EBPM方法增强了临床决策.
- 这一综合战略有望通过量身定制的医疗护理改善患者的治疗结果.
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