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肥胖和糖尿病前期患者的心脏自主活动和低度炎症之间的相互关系
Rumyana Dimova1,2, Tsvetalina Tankova1,2, Nevena Chakarova1,2
1Department of Endocrinology, Medical University of Sofia, Sofia, Bulgaria.
概括
交感性 (SNS) 和副交感性 (PSNS) 活动随着糖尿病前期患者的葡萄糖耐受性恶化而下降. PSNS活动与血压和炎症相反相关,但这种联系主要是由于内脏肥胖.
科学领域:
- 自主神经系统生理学 自主神经系统生理学
- 代谢健康研究 代谢健康研究
- 炎症和慢性疾病的疾病.
背景情况:
- 肥胖和糖尿病前期与自主功能障碍有关.
- 了解自主功能,葡萄糖代谢和炎症之间的相互作用对于管理代谢健康至关重要.
研究的目的:
- 评估在患有肥胖症和不同糖尿病前期状态的个体中交感性 (SNS) 和副交感性 (PSNS) 神经系统活动.
- 在这个人群中确定自主功能和炎症标志物之间的关联.
主要方法:
- 104名患有肥胖症的参与者被分为正常葡萄糖耐受性,高1小时血葡萄糖和受损葡萄糖耐受性组.
- 使用ANX-3.0系统评估自主功能,以及口服葡萄糖耐受性测试,身体组成分析和炎症标志物的测量 (例如CRP,IL-6).
主要成果:
- 观察到PSNS和SNS活动的逐渐下降,葡萄糖耐受性恶化.
- 在年龄调整后,PSNS活性与缩血压和C反应蛋白 (CRP) 呈反向关系.
- 由腰围表示的内脏肥胖症成为减少PSNS活动的主要独立预测因素,解释了其26%的变异.
结论:
- 自主功能障碍,特别是PSNS活动减少,与糖尿病前期和肥胖有关.
- 虽然PSNS活动与血压和炎症相关,但这种关系显著受到内脏脂肪的介导.
- 针对内脏肥胖症可能是改善代谢障碍患者自主功能的关键.
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