相关实验视频
Updated: Feb 13, 2026

10:42
Oral Biofilm Sampling for Microbiome Analysis in Healthy Children
Published on: December 31, 2017
17.9K
口服瓦拉基克洛维尔有效治疗急性视网膜色素表皮炎,在那些对单独口服类固醇无反应的情况下
Jonathan Malcolm Chavan1, Radhika T1, Rathinam Sr1
1Uvea Services, Aravind Eye Hospitals and Postgraduate Institute of Ophthalmology, Madurai, India.
Ocular immunology and inflammation
|February 11, 2026
概括
口服瓦拉克洛维尔有助于急性视网膜色素表皮炎 (ARPE) 患者的康复,这些患者对类固醇无反应. 这种抗病毒疗法促进了视网膜外层的再生,改善了视力敏度,为这种罕见的疾病提供了新的治疗途径.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 病毒学 病毒学
背景情况:
- 急性视网膜色素表皮炎 (ARPE) 是一种罕见的疾病,其病因和病理生理不清楚.
- 治疗挑战存在,因为它很少发生,对系统性类固醇等标准疗法的反应也很有变化.
研究的目的:
- 为了研究口服瓦拉基克洛维尔在ARPE耐系统性类固醇治疗的患者中的疗效.
- 评估Valacyclovir在ARPE病例中对视网膜结构和视力敏度的影响.
主要方法:
- 针对3名被诊断患有ARPE的患者进行了一系列病例.
- 患者最初接受了全身类固醇;随后的治疗涉及口服Valacyclovir治疗持久性疾病.
- 用光学一致性断层扫描 (OCT) 和最佳校正视觉敏度 (BCVA) 来进行评估.
主要成果:
- 这三名患者均表现出视网膜外层的再生,并且在治疗了瓦拉基克洛维尔后改善了BCVA.
- 在两个案例中,观察到海域和国外地区的间区域 (IZ) 完全恢复.
- 在一个案例中,观察到部分IZ再生,与残留视力敏度缺陷相关.
结论:
- 抗病毒疗法,特别是口服瓦拉基克洛维尔,对于对全身类固醇无反应的ARPE病例可能是可行的治疗选择.
- 当ARPE没有自我限制,视力敏度继续下降时,需要考虑抗病毒治疗.
相关概念视频
Oral Cavity
3.2K
The oral cavity, or the mouth, is a complex structure in humans that plays a vital role in our day-to-day lives. Its role is not only in chewing and swallowing food; it also plays a role in speech and facial expressions.
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...
3.2K
Oral Hypoglycemic Agents: Glinides
693
Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively...
693
Psychosexual Stages of Personality: Oral
3.2K
The oral stage is the initial phase of Sigmund Freud's theory of psychosexual development, occurring from birth to approximately 12 to 18 months. During this period, the infant's mouth serves as the primary source of pleasure, with actions such as sucking, chewing, biting, and drinking playing a crucial role in reducing tension. These activities are essential not only for nourishment but also for the infant's psychological and emotional satisfaction.
Weaning, typically occurring...
Weaning, typically occurring...
3.2K
Oral Hypoglycemic Agents: Sulfonylureas
1.2K
Sulfonylureas are oral hypoglycemic agents utilized in treating type 2 diabetes. They are characterized by their unique sulfonylurea chemical structure. The family of sulfonylureas is divided into generations. First-generation sulfonylureas, including tolbutamide (Orinase), chlorpropamide (Diabinese), and tolazamide (Tolinase), trigger insulin release from pancreatic β cells and enhance peripheral tissues' insulin sensitivity. The second-generation members, such as glipizide...
1.2K
Assessing Body Temperature - Oral
1.7K
Here are the steps to accurately measure oral temperature using an electronic thermometer:
Step 1:
Start by practicing proper hand hygiene to prevent the spread of microorganisms.
Step 2:
Take the thermometer out of the charging unit, switch it on, and wait for the ready sign.
Step 3:
Gently slide the probe cover until a click is heard. This simple action prevents cross-contamination and ensures the correct placement of the probe cover.
Step 4:
Instruct the patient to open their mouth and place...
Step 1:
Start by practicing proper hand hygiene to prevent the spread of microorganisms.
Step 2:
Take the thermometer out of the charging unit, switch it on, and wait for the ready sign.
Step 3:
Gently slide the probe cover until a click is heard. This simple action prevents cross-contamination and ensures the correct placement of the probe cover.
Step 4:
Instruct the patient to open their mouth and place...
1.7K
Non-Oral Extravascular Drug Absorption Routes
547
Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
547

