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Updated: Feb 13, 2026

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针对SARS-CoV-2小分子直接作用抗病毒药物的人类剂量预测的最佳临床前模型

Francesca Toselli1, Sofie Jacobs1, Els Scheers1

  • 1Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, Belgium.

Antiviral research
|February 11, 2026
PubMed
概括

预测COVID-19药物的有效人体剂量需要仔细的临床前模型选择. 试验室和K18-hACE2小鼠模型最好地预测了SARS-CoV-2抗病毒药物的人类疗效,例如恩西特里尔维尔和尼尔马特里尔维尔.

关键词:
在K18-hACE2鼠标中,这就是SARS-CoV-2病毒.空气-液体接口的接口.直接作用的抗病毒药物.人类剂量预测.临床前模型的可翻译性

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