基于norbornene二氧化二化改性奇托的pH响应性水凝的结构和素释放性能,通过乙烯光环联结通过乙烯光环联结
Ying Yu1, Yonggang Peng1, Sekar Vijayakumar1
1College of Material Science and Engineering, Huaqiao University, Engineering Research Center of Environment-Friendly Functional Materials, Ministry of Education, Xiamen, 361021, China.
International journal of biological macromolecules
|February 11, 2026
概括
开发了一种基于酸盐的新型水凝,用于持续递送黄素. 这种适应pH值的材料具有抗氧化,抗菌和生物相容性质,使其对药物输送和伤口愈合具有前景.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 药物输送系统 药物输送系统
背景情况:
- 黄素 (Cur) 具有治疗潜力,但其生物可用性较差.
- 开发有效的输送系统对于提高黄素治疗疗效至关重要.
- 响应pH的水凝在特定的生理环境中具有可控释放能力.
研究的目的:
- 开发一种基于奇托桑的新型pH响应型水凝,用于持续的黄素输送.
- 创建一个具有抗氧化和抗菌性能的多功能水凝.
- 评估水凝在口服控制药物递送和伤口愈合方面的性能.
主要方法:
- 用诺波二碳酸二化物修改生素,并通过UV诱导的乙烯化学与氨酸修饰的Pluronic F127进行交叉连接.
- 使用NMR,FTIR,TGA,XRD,SEM和风湿学进行水凝表征.
- 在体外评估药物负载,pH响应释放动力学 (Peppas-Sahlin模型),抗氧化活性 (DPPH,Folin-Ciocalteu,phosphomolybdenum试验),抗菌功效 (金黄色葡萄球菌,大肠杆菌) 和生物相容性 (CCK-8,血液溶解试验).
主要成果:
- 优化的水凝 (NC4) 显示药物载荷能力为13.3 mg/g.
- 观察到pH响应释放,匹配Peppas-Sahlin模型与Fickian扩散动力学 (R2 > 0.98).
- NC4表现出高的DPPH激素清除效率 (~90%),显著的抗氧化能力,强大的抗菌活性和出色的生物相容性 (细胞活力>90%,血液溶解<0.35%).
结论:
- 开发的基托基水凝是一种具有持续释放,抗氧化和抗菌性能的多功能材料.
- 它的优良生物相容性支持其在口服控制药物输送方面的潜力.
- 这种水凝平台对药物输送和伤口愈合的应用非常有前途.
相关概念视频
01:22Modified-Release Drug Delivery Systems: Drug Release Characteristics
1
Drug release from modified-release dosage forms is designed to achieve specific therapeutic effects by controlling the rate and extent of drug release. The classification of these drug release systems is based on key pharmacokinetic assumptions: drug disposition follows first-order kinetics, drug release is the rate-limiting step in absorption, and the released drug is rapidly and completely absorbed.There are four major models of drug release patterns. The first model is the slow zero-order...
1
01:30Modified-Release Drug Delivery Systems: Bioavailability
1
Modified-release (MR) dosage forms are designed to extend drug release over time, thereby maintaining stable plasma concentrations and reducing dosing frequency. However, their bioavailability is typically below 100% due to incomplete drug release and presystemic metabolism, and limitations in drug permeability across the gastrointestinal epithelium, all of which can restrict the fraction of the drug reaching systemic circulation. Consequently, studying the in vivo bioavailability of MR...
1
01:19Reactions of Acid Anhydrides
5.2K
The reactions of acid anhydrides are analogous to the reactions of acid chlorides and proceed via a nucleophilic acyl substitution. They only differ in the identity of the leaving group. During an acid chloride reaction, the leaving group is a chloride ion, and the by-product is hydrochloric acid. However, in an acid anhydride reaction, the leaving group is a carboxylate ion, and the by-product is a carboxylic acid.
5.2K
01:19Modified-Release Drug Delivery Systems: Overview
2
Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
2
01:23Modified-Release Drug Delivery Systems: Classification
1
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
1
01:24Modified-Release Drug Delivery Systems: Site-Targeted
1
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
1