相关实验视频
Updated: Feb 13, 2026

Dissection of Human Retina and RPE-Choroid for Proteomic Analysis
Published on: November 12, 2017
综合蛋白质和基基分析表明,S-基化在近视病原发生期间的冠状腺失调中起着作用
Yuhang Liu1, Xiaohang Chen2, Ji Kou1
1Department of Ophthalmology and laboratory of optometry and vision sciences, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Department of Ophthalmology, West China School of Medicine, Sichuan University, Chengdu, Sichuan, China.
近视的进展涉及冠状腺S-化 (SNO) 的变化,这是一个关键的翻译后修改. 这项研究揭示了SNO驱动的影响细胞骨完整性和铁亡的途径,为近视提供了潜在的治疗点.
科学领域:
- 眼科医生 眼科 眼科
- 蛋白质组学是指蛋白质组学.
- 翻译后修改 翻译后修改
背景情况:
- 近视是一种与胆道功能障碍相关的全球健康问题.
- 在近视病变发生过程中S-化 (SNO) 的作用尚不清楚.
研究的目的:
- 在近视模型中研究状S-化和蛋白质组变化.
- 在近视进展中识别S-化驱动的调节途径.
主要方法:
- 在使用透镜磨损的几内亚猪中诱导近视.
- 评估了眼睛的变化,冠状腺厚度和全球S-化.
- 通过使用LC-MS/MS进行了综合蛋白质和S-基形分析.
- 使用生物信息分析来识别SNO调节蛋白.
主要成果:
- 透镜诱导的近视导致了显著的轴延长和胆道细化.
- 在近视患者中,总状S-化蛋白水平升高.
- 鉴定了1293种具有SNO变化的蛋白质,不依赖于丰度,涉及细胞骨,突触和铁亡途径.
结论:
- 确立S-化作为近视的关键调节层.
- 表明SNO介导的途径失调有助于近视诱导的胆道功能障碍.
- 确定了近视干预的潜在治疗点.
更多相关视频
07:35Laser Microdissection-Based Protocol for the LC-MS/MS Analysis of the Proteomic Profile of Neuromelanin Granules
Published on: December 16, 2021
10:31Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
相关概念视频
Proteomics
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
Pulmonary Hypertension: Classification and Pathogenesis
There are various classifications for PH, each relating to different underlying causes and also...
Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Cystic Fibrosis: Pathogenesis
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Integration by Parts: Indefinite Integrals