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肠道环境中微塑料诱导的变化:衰老作为调节因素

Alicia Sánchez1, Diego Ríos1, Mireia Mártinez1

  • 1Instituto de Agroquímica y Tecnología de Alimentos (IATA-CSIC), Calle Agustín Escardino 7, 46980 - Paterna (Valencia), Spain.

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概括

饮食中的微塑料 (MP) 破坏肠道健康,导致氧化应激和炎症. 国会议员的环境老化可能会改变其毒性,影响肠道平衡和微生物群组成.

关键词:
在这里,PVC是PVC.这是一种炎症炎症炎症炎症.肠道毒性 肠道毒性我们的微生物群.微塑料微塑料的使用短链脂肪酸 短链脂肪酸

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科学领域:

  • 环境科学 环境科学
  • 毒理学 毒理学 毒理学
  • 微生物学 微生物学

背景情况:

  • 饮食中的微塑料 (MP) 越来越多地被认为是环境污染物,具有潜在的健康影响.
  • 之前的研究经常使用非老化的颗粒,不反映现实世界MP暴露和毒性.
  • 环境老化可能会改变MP的物理和化学特性,可能会影响其生物效应.

研究的目的:

  • 为了研究经过次慢性口服暴露后老化和未老化的PVC微塑料的体内肠道毒性.
  • 评估PVC MPs对氧化应激,炎症,肠道微生物群和肠道组织学的影响.
  • 为了确定颗粒老化是否影响肠道中微塑料的毒性.

主要方法:

  • 雌性BALB/c小鼠在70天内用老化或未老化的PVCMP (0.02mg/天) 口服.
  • 评估了氧化应激标志物 (ROS / RNS,脂质过氧化),炎症性细胞因子 (IL-1β,TNF-α),组织学变化,肠道微生物群和便专.
  • 使用微波辅助消化和μRaman光谱学的量化MP积累.

主要成果:

  • 老化和非老化PVCMP都引起了显著的氧化应激和肠道炎症.
  • 组织学分析显示,密室深度降低,粘液分泌细胞增加.
  • 暴露于MP改变了肠道微生物群的组成,降低了短链脂肪酸 (SCFA) 水平,并且显示了老化和非老化颗粒之间的毒性差异.

结论:

  • 长期暴露在PVC微塑料下会通过氧化应激,炎症和肠道失调破坏肠道平衡.
  • 微塑料的衰老过程可以调节它们的肠道毒性.
  • 这些发现强调了在评估微塑料对肠道健康的风险时考虑环境衰老的重要性.