癌症和抑郁症之间的双向关系:从共享机制到综合治疗策略
Zichen Liu1, Jiaming Wan1, Shupeng Liu2
1School of Alberta Institute, Wenzhou Medical University, Wenzhou, China.
Cancer letters
|February 11, 2026
概括
癌症和抑郁症具有显著的双向联系. 癌症患者经常经历抑郁症,影响治疗和生存. 抑郁症也会增加癌症的风险,这凸显了综合护理策略的必要性.
科学领域:
- 在瘤学瘤学.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
背景情况:
- 癌症和抑郁症之间存在着显著的双向关联.
- 抑郁症在癌症患者中很常见,导致结果较差.
- 抑郁症与患癌症的风险增加有关.
研究的目的:
- 探索癌症和抑郁症之间的复杂关系和共同机制.
- 确定综合治疗策略的潜在治疗目标.
主要方法:
- 对癌症与抑郁症的联系进行现有文献的审查.
- 分析共享的生物通路,包括神经免疫,炎症和肠-大脑轴.
- 检查导致这两种情况的生活方式因素.
主要成果:
- 共有的机制包括压力信号,神经炎症,金氨酸通路和肠-大脑-瘤轴.
- 吸烟和睡眠障碍等生活方式因素进一步将癌症和抑郁症联系起来.
- 由诸如慢性炎症和神经免疫失调等因素介导的双向关联.
结论:
- 结合抗炎药物,精神药物,生活方式改变和心理治疗的综合治疗方法是有希望的.
- 解决抑郁症-癌症循环对于改善患者的治疗结果至关重要.
- 了解共同的途径可以导致新的治疗干预措施.
相关概念视频
Relationship Formation
46.3K
What do you think is the single most influential factor in determining with whom you become friends and whom you form romantic relationships? You might be surprised to learn that the answer is simple: the people with whom you have the most contact. This most important factor is proximity. You are more likely to be friends with people you have regular contact with. For example, there are decades of research that shows that you are more likely to become friends with people who live in your dorm,...
46.3K
Techniques of therapeutic communication I: Active Listening, Sharing Observations, Validation, and Using Touch
8.1K
The history of therapeutic communication can be traced back to Florence Nightingale, who emphasized the importance of developing trusting relationships with patients. She taught that the presence of nurses with patients results in therapeutic healing.
Therapeutic communication is not the same as social interaction. Social interaction has no goal or purpose and consists of casual information sharing, whereas therapeutic communication has a plan or purpose for the conversation. Therapeutic...
Therapeutic communication is not the same as social interaction. Social interaction has no goal or purpose and consists of casual information sharing, whereas therapeutic communication has a plan or purpose for the conversation. Therapeutic...
8.1K
Long-term Depression
33.4K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.4K
Adaptive Mechanisms in Cancer Cells
7.2K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
7.2K
Mechanisms of Retrovirus-induced Cancers
7.0K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
7.0K
Freezing Point Depression and Boiling Point Elevation
40.5K
Boiling Point Elevation
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
40.5K


