在糖尿病神经病变,认知障碍和情绪障碍中,肠-大脑轴
Xiao Yu1, Kexin Zhang2, Chengxia Kan1
1Department of Endocrinology and Metabolism, Shandong Provincial Key Medical and Health Laboratory of Endocrinology and Metabolic Diseases, Affiliated Hospital of Shandong Second Medical University, Weifang, China; Clinical Research Center, Affiliated Hospital of Shandong Second Medical University, Weifang, China.
肠-大脑轴 (GBA) 显著影响糖尿病. 肠道微生物群和屏障功能的干扰促进胰岛素耐药性和糖尿病发病,提供新的治疗点.
科学领域:
- 内分泌学 在内分泌学.
- 微生物学 微生物学
- 神经科学是一个神经科学.
背景情况:
- 糖尿病是一种日益严重的全球健康问题,具有重大的社会经济影响.
- 肠-大脑轴 (GBA),一个双向通信网络,越来越多地被认为是其在代谢疾病中的作用.
- GBA涉及神经元,内分泌和免疫路径连接肠道微生物群,肠道屏障和大脑.
研究的目的:
- 探索肠-大脑轴在糖尿病病变发生过程中的作用.
- 突出肠道微生物群,肠道屏障功能和糖尿病发展中的神经内分泌因素之间的联系.
- 根据GBA研究,确定糖尿病的新型治疗策略.
主要方法:
- 审查关于肠-大脑轴和糖尿病的现有研究.
- 分析肠道微生物群失调和肠道屏障功能受损对胰岛素耐药性的影响.
- 研究由GBA在糖尿病发病过程中影响的神经内分泌路径.
主要成果:
- 肠道微生物群的失衡和肠道屏障完整性的损害与胰岛素抵抗和糖尿病有关.
- 由肠道屏障功能受损造成的肠道菌群代谢物和系统性炎症会影响胰岛素敏感性.
- GBA失调影响食欲,能量平衡和胰岛素分泌,加速糖尿病.
结论:
- 在糖尿病病原发生过程中,GBA扮演着多维的角色.
- 调节肠道微生物组,恢复肠道屏障完整性,纠正神经内分泌失调是糖尿病的潜在治疗途径.
- 了解GBA为治疗糖尿病及其并发症提供了有希望的策略.
更多相关视频
07:21The Emotional Stroop Task: Assessing Cognitive Performance under Exposure to Emotional Content
Published on: June 29, 2016
08:25Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans
Published on: May 19, 2016
相关概念视频
Cognitive Theories: Schachter-Singer Theory of Emotion
Physiological Arousal and Cognitive Labeling
According to this theory, when an individual experiences...
Cognitive Theories: Lazarus Mediational Theory of Emotion
Cognitive Appraisal and Emotional Response
Lazarus proposed that...
Cognitive Dissonance
Hypothalamic-Pituitary Axis
Physiology of Emotion
Autonomic Nervous System
The autonomic nervous system (ANS) plays a critical role in emotional responses by regulating involuntary physiological functions. It consists of two main components: the sympathetic and parasympathetic systems. The sympathetic system...
Emotional Expression
Universal Facial Expressions
Psychologist Paul Ekman identified seven basic...
