患者报告的结果 随着加速与标准TMS与H1卷轴的主要抑郁症:一个多站点随机试验
Aron Tendler1, Yiftach Roth2, Mallory Bates3
1DTMS Center, West Palm Beach, FL 33401.
Brain stimulation
|February 11, 2026
概括
加快式体磁性刺激 (ACC-iTBS) 提供了与主要抑郁症 (MDD) 标准治疗相比,患者报告的结果相当. 这种更快的TMS方法提供更快的症状缓解和改善患者满意度.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 临床试验 临床试验
背景情况:
- 临床医生评估的措施是抑郁症试验的标准.
- 患者报告的结果 (PROs) 提供了关键的现实洞察力.
- 大型抑郁症 (MDD) 需要有效的治疗选择.
研究的目的:
- 在MDD患者中,加速H1-coil TMS (ACC-iTBS) 和标准每天一次高频H1-coil TMS (SOC-HF) 之间的PROs进行比较.
- 评估反应/缓解率,感知改善的时间和生活质量变化.
- 评估不同TMS协议的以患者为中心的好处.
主要方法:
- 随机,多站点试验涉及104名中度至重度MDD的成年人.
- 干预组:ACC-iTBS (六天每天五次会议) 与SOC-HF (每天四周的会议).
- 评估的PROs:临床有用的抑郁症结果表 (CUDOS-D),临床有用的焦虑结果表 (CUXOS-D),生活质量享受和满意度问卷 (Q-LES-Q).
主要成果:
- 无论是ACC-iTBS还是SOC-HF,都在抑郁症,焦虑症和生活质量方面表现出相似的改善.
- ACC-iTBS显示,CUDOS反应的中位时间显著缩短 (11 vs. 16 天).
- 严重的生活质量下降显著从基线在两个小组下降到第6周.
结论:
- ACC-iTBS为患者提供类似于MDD标准TMS的感知效益.
- 与SOC-HF相比,ACC-iTBS可以更快地缓解抑郁症状.
- ACC-iTBS可以提高MDD的治疗可用性和患者满意度.
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