雌激醇通过上调ESR2/SP1转录因子介导的poFUT2表达来促进 trofhoblasts 的合成
1Liaoning Provincial Core Lab of Glycobiology and Glycoengineering, College of Basic Medical Science, Dalian Medical University, Dalian, Liaoning, China.
Molecular and cellular endocrinology
|February 11, 2026
概括
雌激醇通过雌激素受体2 (ESR2) /SP1复合体对O-fucosyltransferase 2 (poFUT2) 进行高调节,促进热囊细胞融合和分化,这对胎盘发育至关重要.
科学领域:
- 生殖生物学 生殖生物学
- 细胞生物学 细胞生物学
- 生物化学 生化学
背景情况:
- 合成细胞 (STB) 对于胎盘功能至关重要,由细胞细胞 (CTB) 融合形成.
- 雌激醇和蛋白质糖化化与热囊细胞同胞化有关.
- O-fucosyltransferase 2 (poFUT2) 参与胎盘发育,但其在合成化中的作用尚不清楚.
研究的目的:
- 为了研究雌激醇-poFUT2轴在热囊细胞合成中的功能.
- 阐明基因质细胞中以雌激醇为媒介的poFUT2调节的分子机制.
主要方法:
- 免疫组织化学评估胎盘组织中的poFUT2表达.
- 在体外细胞模型中研究热囊细胞同胞化.
- 染色体免疫沉降和共免疫沉降测试以确定调节相互作用.
主要成果:
- 在先兆子患者的同胞细胞中,poFUT2的表达减少.
- poFUT2的过度表达在体外促进了 trofhoblast细胞的融合.
- 雌激醇上调了poFUT2的表达,并增强了同位素的形成.
- 雌激素受体2 (ESR2) 和SP1调节雌激素对poFUT2基因的调节.
结论:
- 雌激醇通过ESR2/SP1复合体调节poFUT2的表达.
- 这种雌激醇-poFUT2轴促进了 trofhoblast 的分化和融合.
- 这些发现突出了调节胎盘发育的新机制,可能与孕前有关.
相关概念视频
02:16Transcription Factors
82.9K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.9K
02:35Transcription Elongation Factors
14.1K
Transcription elongation is a dynamic process that alters depending upon the sequence heterogeneity of the DNA being transcribed. Hence, it is not surprising that the elongation complex's composition also varies along the way while transcribing a gene.
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA...
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA...
14.1K
02:35Transcription Elongation Factors
4.8K
4.8K
01:30General Transcription Factors
7.2K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
7.2K
02:40The Eukaryotic Promoter Region
19.0K
The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences. The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
19.0K
02:23Master Transcription Regulators
7.8K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.8K