在使用组合激素避孕药的女性中,女性生殖器兴奋
Giuseppe Caruso1, Salvatore Caruso2, Claudia Santangelo1
1Department of General Surgery and Medical Surgical Specialties, Gynecological Clinic, School of Medicine, University of Catania, Catania, Italy.
概括
含有乙inylestradiol (EE) 的荷尔蒙避孕药 (HC) 与含有天然雌激素的药物相比,与较低的性兴奋和滑有关. 较高的自由雄激素指数 (FAI) 与性功能有正相关,而阴蒂血流则显示出反向关系.
科学领域:
- 内分泌学 在内分泌学.
- 性健康 性的健康
- 药理学 药理学是指药理学的学科.
背景情况:
- 激素避孕药 (HCs) 被生育年龄的女性广泛使用.
- 不同配方的HC,在雌激素和孕激素成分上有所不同,可能会影响女性的性功能.
- 了解这些影响对于个性化避孕选择至关重要.
研究的目的:
- 在使用各种HC的女性中,研究性功能 (兴奋,滑) 和荷尔蒙特征 (自由雄激素指数-FAI) 之间的相关性.
- 评估不同类型的雌激素 (乙inylestradiol - EE,oestradiol valerate - E2V,17β-oestradiol - E2,estetrol - E4) 和抗雄激素孕激素对性反应的影响.
- 为了评估阴蒂血流与女性性功能之间的关系,使用不同的HC.
主要方法:
- 132名女性 (18-41岁) 填写了关于性功能 (FSFI) 和痛苦 (FSDS) 的验证问卷.
- 测量激素水平 (SHBG,TT) 用于计算FAI.
- 穿肌色 多普勒超声波评估的阴蒂动脉脉动指数 (PI).
主要成果:
- 与使用E2V,E2或E4的女性相比,使用EE的HC的女性报告的兴奋和滑得分较低.
- 与含有EE的HC观察到较低的FAI,而天然雌激素与较高的FAI有关.
- 性兴奋和滑得分与FAI正相关.
- 与EE相比,阴蒂动脉PI较低,与自然/本地雌激素相比,与FAI负相关.
结论:
- 少数使用含有EE的HC的女性可能会经历性兴奋和阴道滑的减少.
- 与天然和本地雌激素结合的口服避孕药 (COCs) 与含有EE的药物相比,可能为性功能提供更好的结果.
- 这些发现强调了雌激素类型在HC中对维持女性性健康的重要性.
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