微针贴片增强的口腔麻醉与本佐卡因:在一个随机双盲交叉试验的有效性和安全性
Kensuke Kiriishi1, Terumi Ayuse1, Naomi Tanoue2
1Department of Special Care Dentistry, Nagasaki University Hospital, Nagasaki, Japan.
Drug discoveries & therapeutics
|February 11, 2026
概括
与安慰剂相比,本佐卡因微针 (MN) 补丁在牙科麻醉期间显著减少了针插入疼痛. 这种创新方法提供了一种更安全,更有效的方式来管理与注射相关的牙焦虑.
科学领域:
- 牙科麻醉学 牙科麻醉学
- 药物输送系统 药物输送系统
- 最少侵入性手术的方法
背景情况:
- 在牙科局部麻醉中,注射针的疼痛是患者焦虑的主要原因.
- 传统的局部麻醉剂在厚厚的 palatal 粘膜上有效性有限.
- 微针 (MN) 贴片提供增强的跨粘膜药物输送.
研究的目的:
- 评估佐卡因载满的MN贴片在口腔麻醉期间减少针插入疼痛的疗效和安全性.
- 在随机,双盲,交叉试验中,将MN贴片与安慰剂贴片进行比较.
主要方法:
- 一个随机,双盲,交叉试验,涉及20名接受牙科手术的成年患者.
- 在局部麻醉之前,将含可因的MN贴片或安慰剂贴片应用于 palatal 粘膜.
- 评估针插入疼痛,注射阶段疼痛 (视觉模拟量表) 和不良事件.
主要成果:
- 针插入疼痛发生在10%的MN贴片患者中,与安慰剂患者的70%相比 (p = 0.00049).
- 两组之间没有观察到注射阶段疼痛的显著差异.
- 该MN贴片表现出了卓越的安全性,没有显著的不良事件.
结论:
- 含有本佐卡因的MN贴片有效地减少了在牙科麻醉期间的表面针插入疼痛.
- MN辅助的粘膜间麻醉是一种有希望的,最少侵入性的选择,用于管理牙科焦虑.
- 口腔粘膜的实质性厚度可能会限制MN贴片对更深的注射疼痛的疗效.
关键词:
微针贴片微针贴片班佐卡因 (benzocaine) 是一种可靠的药物.牙科局部麻醉 牙科局部麻醉palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthesia palatal anesthetized by means of which is used to describe what is being said随机交叉试验是指随机交叉试验.更多相关视频
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