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Updated: Feb 13, 2026

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偶然的MSH6生殖系致病变体通过在患有小细胞肺癌的患者中仅进行瘤综合基因组分析来确定

Hideto Ishimoto1, Mikako Miyata2, Chiyomi Otsuka2

  • 1Department of Respiratory Medicine, Toyonaka Municipal Hospital, Japan.

Internal medicine (Tokyo, Japan)
|February 11, 2026
PubMed
概括

综合性基因组分析在一个小细胞肺癌患者中发现了生殖系MSH6突变,证实了林奇综合征. 这凸显了瘤到胚芽细胞检测对于家族查和变异解释的重要性.

关键词:
综合性基因组分析分析发生生殖线突变的生殖线突变林奇综合征是什么? 林奇综合征是什么?在MSH6中,MSH6是MSH6.不匹配的修复缺陷的缺陷小细胞肺癌是一种小细胞肺癌.

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