甲状腺狭窄症风险分层的斑块-RADS和新血管化:双模成像研究
Huan Zhu1, Qihang Zhang1, Tong Liu1
1From the Beijing Neurosurgical Institute (H.Z., Q.Z., T.L., C.Z., T.Y., T.Y., X.L., Q.Z., J. Z., Y.Z.), Capital Medical University; Department of Neurosurgery (Q.Z., T.L., C.Z., T. Y., T.Y., X.L., Q.Z., J.Z., Y.Z.), Beijing Tiantan Hospital, Capital Medical University; Department of Radiology (T.C.), Beijing Tiantan Hospital, Capital Medical University; Department of Neurosurgery (W.L.), Peking University Third Hospital; Department of Neurosurgery (P.W.), The First Affiliated Hospital of Zhengzhou University; and China National Clinical Research Center for Neurological Diseases (W.L.).
Carotid Plaque-RADS评分和内新血管化 (IPN) 是独立的成像生物标志物. 结合起来,它们有效地识别了近期大脑血管事件在患有动脉狭窄症的患者.
科学领域:
- 血管成像 血管成像
- 脑血管疾病研究研究
- 生物标志物发现发现
背景情况:
- 评估状腺斑块的脆弱性对于中风风险分层至关重要.
- 内斑内新血管化 (IPN) 与动脉样硬化斑块的进展有关.
- 斑块-RADS,IPN和症状性动脉狭窄症之间的关系需要进一步澄清.
研究的目的:
- 为了研究状板-RADS得分和IPN之间的相互关系.
- 评估它们的组合和单独作用,以确定近期大脑血管事件在患有大脑动脉狭窄的患者.
主要方法:
- 对128名患有动脉狭窄症的患者进行了回顾性分析.
- 综合性斑块表征,使用耳磁共振器壁成像和对比增强超声波.
- 使用AUC,NRI和IDI开发和评估了后勤回归模型.
主要成果:
- 症状狭窄的患者表现出较高的斑块-RADS得分,IPN等级和斑块体积.
- 斑块-RADS和IPN都与症状出现以来的持续时间相反相关.
- 与单指标模型相比,Plaque-RADS和IPN的组合模型显示出优越的预测性能.
结论:
- Carotid Plaque-RADS评分和IPN等级是独立的和互补的成像生物标志物.
- 这些生物标志物对于识别近期大脑血管事件在动脉狭窄患者是有价值的.
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