缺血性中风中的时间成像动态:基于强度与体积的指标.
Horst Urbach1, Alexander Rau2, Ömer Bagcilar2
1From the Dept. of Neuroradiology, Medical Center - University of Freiburg, Faculty of Medicine (H.U., A.R., Ö.B., E.K.), University of Freiburg; Center for Stroke Research Berlin (I.G., J.F.), Charite - Universitätsmedizin Berlin; and Dept. of Medical Physics, Medical Center, University of Freiburg, Faculty of Medicine (M.R., E.K.), University of Freiburg. horst.urbach@uniklinik-freiburg.de.
在急性缺血性中风中,组织信号强度随着时间的推移而变化更多,而不是体积测量. 这表明心脏病发作的进化是逐渐的组织损伤,而不仅仅是扩张,强度指标更好地反映了这种变化.
科学领域:
- 神经学 神经学
- 放射学 放射学是一门学科.
- 生物医学成像技术 生物医学成像技术
背景情况:
- 血栓栓塞堵塞后缺血组织损伤的进展受到低输液和再输液时间的影响.
- 在急性缺血性中风中,低输液和组织损伤的时间动态仍然不完全理解.
研究的目的:
- 为了比较在急性缺血性中风中开始到成像时间和体积与强度基成像标记器之间的关联.
- 为了研究不同的成像方式 (CT和MRI) 和指标如何反映随着时间的推移组织损伤.
主要方法:
- 对288次CT和275次MRI急性中风检查的回顾性分析.
- 使用VEOcore软件与标准值估计低 perfusion和心脏病发作核心体积.
- 使用ASPECTS和规范信号强度 (NCCT,ADC,DWI,CBF,Tmax) 来量化组织损伤.
- 使用多变量线性回归来评估与开始到成像时间的关联,并对共变量进行调整.
主要成果:
- 体积测量显示时间依赖性有限:ASPECTS减少了0.33点/小时,ADC核心体积增加了1.8毫升/小时.
- 与 perfusion 相关的体积测量 (CBF < 30%,Tmax > 6s) 没有随着时间的推移发生显著变化.
- 强度测量显示出显著的时间依赖性:NCCT强度下降了-1.1%/h,ADC强度下降了-0.69%/h,而DWI-b0和DWI-b1000分别增加了2.3%/h和4.9%/h.
结论:
- 在急性缺血性中风中,组织信号强度与体积测量相比,表现出更强的时间依赖.
- 心脏病的演变似乎反映了渐进的组织损伤,而不是仅仅是体积膨胀.
- 来自NCCT和DWI的基于强度的指标可能比基于 perfusion 的指标更适合评估"心脏病增长率".
更多相关视频
06:45Author Spotlight: Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT) for NonInvasive Whole-Brain Imaging of Ischemic Stroke
Published on: June 2, 2023
07:34Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research
Published on: December 15, 2023
相关概念视频
Regulation of Stroke Volume
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
Cardiac Output and Stroke Volume
In an average resting adult male, the typical cardiac...
Cardiac Output II: Effect of Stroke Volume on Cardiac Output
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
Sound Intensity
Sound Intensity Level
The human ear can perceive an extensive range of sound intensity, necessitating the use of the logarithmic scale to define a physical quantity—the intensity level. It is a ratio of two intensities and...
Intensity Of Electromagnetic Waves
![PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F57243.jpg&w=3840&q=50)