散布的Mycobacterium marinum感染:在免疫受损的主体的诊断和治疗挑战
Wei Hau Ngan1, Masjudin Tumin2, Foong Kee Kan3
1Faculty of Medical Sciences, Newcastle University Medicine Malaysia (NUMed), Newcastle upon Tyne, UK.
BMJ case reports
|February 11, 2026
概括
马林菌菌菌菌感染是一种罕见的动物性传染病. 这一案例突显了免疫受损患者的诊断挑战,强调了包括传统中医在内的彻底的药物历史,以更好地管理和预防传播疾病.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 药物监督 药物监督 药物监督
背景情况:
- 马林菌 (Mycobacterium marinum) 导致罕见的,进展缓慢的动物性传染病.
- 临床表现缺乏明显的特征,通常需要水生暴露史才能怀疑.
- 免疫功能低下的人面临更高的风险和诊断挑战.
研究的目的:
- 为了呈现一个复杂的分布式Mycobacterium marinum感染病例.
- 为了突出诊断延迟和治疗失败在免疫受损患者.
- 强调包括传统中医药 (TCM) 在内的全面药物历史的重要性.
主要方法:
- 案例报告的呈现方式.
- 对临床过程和诊断工作的审查.
- 分析导致诊断延迟和治疗失败的因素.
主要成果:
- 一名患有CD4细胞衰减的患者在1.5年内发展出扩散的M. marinum感染.
- 由于低怀疑和免疫抑制导致诊断延迟导致临床恶化.
- 治疗失败发生了尽管多次抗菌疗程,由TCM的皮质类固醇诱导免疫抑制复杂化.
结论:
- 在免疫功能低下的人群中诊断M. marinum是复杂的.
- 完整的药物历史,包括TCM,对于患者管理至关重要.
- 提高TCM的药物监测对于预防不良事件和阳性免疫抑制至关重要.
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