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Updated: Feb 13, 2026

Purification of Hepatocytes and Sinusoidal Endothelial Cells from Mouse Liver Perfusion
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内皮RAP1A通过抑制RAF1-介导的Notch激活来减弱阴侧毛细体和肝纤维化

Guangwen Chen1, Weiming Dai2, Junjun Wang1

  • 1Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Gut
|February 11, 2026
PubMed
概括

肝脏阴侧内皮细胞 (LSEC) 中的Ras相关蛋白1A (RAP1A) 缺乏通过激活Notch信号来促进毛细化和肝纤维化. RAP1A对于LSEC恒温是必不可少的,也是肝纤维化的潜在治疗点.

关键词:
慢性肝脏疾病 慢性肝脏疾病肝脏纤维化 肝脏纤维化

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