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胃绕道术后体重减轻和生存益处的基准测试:一项长期队列研究
Ramsey M Dallal1, Noah Streitfeld1, Zaid M Haddadin1
1Department of Surgery, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania.
概括
鲁克斯-en-Y胃绕道 (RYGB) 提供了显著的长期减肥和生存益处,特别是对于55岁以上的患者. 这项研究为比较新的肥胖治疗方法,如葡萄糖类-1受体激动剂,建立了关键的基准.
科学领域:
- 腹部外科 腹部外科
- 肥胖管理 肥胖管理
- 手术结果研究研究.
背景情况:
- 越来越多地使用类似葡萄糖类-1受体激动剂治疗肥胖症,需要关于手术结果的长期数据.
- 建立手术手术的基准对于未来的比较疗效研究至关重要.
研究的目的:
- 评估与Roux-en-Y胃绕道 (RYGB) 相关的长期疗效,安全性和生存率.
- 为肥胖治疗中的新兴医学疗法提供一个基准.
主要方法:
- 在社区教学医院对初级RYGB程序 (2006-2011) 的回顾性队列研究.
- 结果包括并发症,死亡率和体重减轻,死亡率与倾向权重的国家队列相比.
- 平均随访时间为11.7年,82%的患者有10年后的数据.
主要成果:
- 在RYGB中,死亡率显著降低 (67%在55-64岁患者中,53%在≥65岁患者中),但在年轻患者中没有显著降低.
- 观察到持久的体重减轻:35%在2年和28.5%在10年.
- 严重的酒精使用障碍影响了至少5%的患者,年轻人面临更高的风险;肝衰竭占死亡人数的16%.
结论:
- 鲁克斯-en-Y胃绕道为55岁及以上的患者提供持久的体重减轻和显著的生存优势.
- 这些发现是评估较新的肥胖治疗方法的关键基准.
- 长期监测诸如酒精使用障碍和肝衰竭等并发症是RYGB后必不可少的.
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