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儿科急性复发性和慢性胰腺炎的长期疾病进展:INSPPIRE的一份报告
Elissa M Downs1, Emily R Perito2, Fuchenchu Wang3
1University of Minnesota, United States.
概括
近五分之一患有急性复发性胰腺炎 (ARP) 的儿童进展为慢性胰腺炎 (CP). 导致CP进展的危险因素包括遗传学和频繁的急性胰腺炎发作.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 胰腺学 胰腺学
背景情况:
- 儿童急性复发性胰腺炎 (ARP) 可以导致慢性胰腺炎 (CP).
- 国际研究小儿胰腺炎研究小组:寻找一个cuRE (INSPPIRE) 队列提供了关于疾病进展的见解.
研究的目的:
- 分析儿童ARP向CP的进展情况.
- 在儿科队列中识别与胰腺炎进展相关的风险因素和后果.
主要方法:
- 将626名儿童分为持续性ARP (pARP),事件性CP (iCP) 或流行性CP (pCP).
- 分析了使用前性收集的数据的进展时间和风险因素.
主要成果:
- 21.1%的ARP病例进展到ICP.
- 事件CP病例更有可能具有PRSS1突变,阻塞因素和更急性胰腺炎发作.
- 在随访期间,24%的儿童出现了外分胰腺功能衰竭 (EPI);32%的ICP病例出现了EPI.
- 在随访期间,8%的人患上了糖尿病 (DM).
结论:
- 几乎五分之一的ARP儿童发展为CP.
- 遗传学,阻塞性疾病和高发作频率是进展的危险因素.
- 一部分儿童出现了EPI和DM等不可逆转的后果.
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