核的不同作用 Accumbens D1-和D2-MSN 在调节快乐的养
Chase A Carter1, Samhitha S Pudipeddi1, Pierre Llorach2
1Department of Psychology and Neuroscience, The University of North Carolina at Chapel Hill, North Carolina 27599.
概括
这项研究揭示了核突中状神经元 (MSN) 亚型在调节享乐性养中的性别特异性作用. 在男性中,D1-MSN活性抑制高脂肪摄入,而在女性中,D2-MSN活性促进高脂肪摄入.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 分子精神病学分子精神病学
背景情况:
- 核心聚合体 (NAc) 对于奖励和激励行为至关重要,其功能障碍与精神疾病有关.
- 中等脊状神经元 (MSN) 在NAc中,分为D1-MSN和D2-MSN亚型,在奖励处理中具有不同的作用.
研究的目的:
- 剖析D1-和D2-MSN对高脂肪饮食的享乐性养的因果贡献.
- 为了研究可口食品消费期间NAc MSN活动的性别特异调节.
主要方法:
- 在Cre-driver小鼠系列中利用光遗传学,化学遗传学 (DREADDs) 和纤维光度学.
- 研究了激活或抑制D1-MSN和D2-MSN对高脂肪饮食消费的影响.
- 在重复接触高脂肪食物时监测D2-MSN活动动态.
主要成果:
- D1-MSN激活抑制了高脂肪摄入量;抑制增加了男性的摄入量,但不是女性.
- D2-MSN激活增加了女性的高脂肪摄入量;抑制减少了两性摄入量.
- 纤维光度显示,D2-MSN活性增加与雌性小鼠摄入量增加相关.
结论:
- D1-MSN和D2-MSN对 hedonic 养产生相反的,性别特定的影响.
- NAc MSN亚型活动根据性别差异调节突出性和消费.
- 研究结果为针对肥胖和强迫性消费障碍的潜在针对性干预提供了信息.
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