铜 - 脊椎蛋白协调纳米颗粒用于逆转胰腺癌治疗中的铁灭抵抗性
Zhen Jiang1, Jiadong Wang1, He Ren1
1School of Synthetic Biology and Biomanufacturing, State Key Laboratory of Synthetic Biology, Frontiers Science Center for Synthetic Biology (Ministry of Education), Tianjin University, Tianjin 300350, P.R. China. ymzhang88@tju.edu.cn.
Nanoscale
|February 11, 2026
概括
胰腺癌由于Xc-/SLC7A11轴和YAP的作用而抵抗铁亡. 一个新的纳米系统,CuVP-F127-IKE-Mem,针对YAP并诱导铁亡,克服抵抗并抑制瘤生长.
科学领域:
- 生物医学工程 生物医学工程
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 铁亡,一种依赖于铁的细胞死亡,对癌症治疗有希望,但在胰腺癌中面临阻力.
- 这种抵抗与过度激活的Xc-/SLC7A11/GSH/GPX4轴和YAP驱动的SLC7A11过度表达有关.
研究的目的:
- 开发一种新的治疗策略,以克服胰腺癌中的铁灭性耐药性.
- 为了研究YAP向的转录调节方法与铁灭诱导相结合.
主要方法:
- 对金属氨酸的查确定了铜氨酸 (CuVP) 作为YAP抑制剂.
- 一个瘤向纳米系统 (CuVP-F127-IKE-Mem) 的开发,集成CuVP和伊米达基埃拉斯 (IKE).
- 在胰腺癌模型中评估纳米系统的pH响应释放,YAP/SLC7A11抑制,氧化还原稳定性破坏和抗瘤功效.
主要成果:
- CuVP-F127-IKE-Mem纳米系统有效地抑制了YAP活动,并降低了SLC7A11转录的调节.
- CuVP和IKE的双重作用协同地破坏了Xc-/SLC7A11/GSH/GPX4防御轴,增强了ferroptosis的敏感性.
- 在活体研究中,胰腺癌模型中显示出显著的瘤生长抑制.
结论:
- 针对YAP的转录调节与ferroptosis诱导相结合,是对抗胰腺癌的有效策略.
- 开发的纳米系统为克服铁灭耐药性和治疗胰腺癌提供了一个新的范式.
相关概念视频
Cancer Therapies
10.2K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K
Treatment Resistant Cancers
3.8K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.8K
Targeted Cancer Therapies
9.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
9.0K
Coordination Number and Geometry
19.1K
For transition metal complexes, the coordination number determines the geometry around the central metal ion. Table 1 compares coordination numbers to molecular geometry. The most common structures of the complexes in coordination compounds are octahedral, tetrahedral, and square planar.
19.1K
Coordination Compounds and Nomenclature
26.9K
In most main group element compounds, the valence electrons of the isolated atoms combine to form chemical bonds that satisfy the octet rule. For instance, the four valence electrons of carbon overlap with electrons from four hydrogen atoms to form CH4. The one valence electron leaves sodium and adds to the seven valence electrons of chlorine to form the ionic formula unit NaCl (Figure 1a). Transition metals do not normally bond in this fashion. They primarily form coordinate covalent bonds, a...
26.9K
Lattice Centering and Coordination Number
12.2K
The structure of a crystalline solid, whether a metal or not, is best described by considering its simplest repeating unit, which is referred to as its unit cell. The unit cell consists of lattice points that represent the locations of atoms or ions. The entire structure then consists of this unit cell repeating in three dimensions. The three different types of unit cells present in the cubic lattice are illustrated in Figure 1.
Types of Unit Cells
Imagine taking a large number of identical...
Types of Unit Cells
Imagine taking a large number of identical...
12.2K


