精制碳水化合物饮食模式与韩国人口肥胖遗传风险评分之间的相互作用
Min-Jae Jang1, Sangwon Chung2, Kyungjoon Lim3
1Department of Animal Science and Technology, Chung-Ang University, Anseong, Gyeonggi-do 17546, Republic of Korea.
Public health nutrition
|February 11, 2026
概括
减少精制碳水化合物摄入量可能有助于韩国成年人高遗传肥胖风险. 这种饮食改变可以减轻遗传倾向对肥胖的影响.
科学领域:
- 遗传学 是一个遗传学.
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 对肥胖的遗传倾向可以增加脂肪.
- 饮食习惯可能与遗传因素相互作用,改变肥胖风险.
- 研究这些相互作用对于个性化肥胖预防策略至关重要.
研究的目的:
- 检查饮食模式如何影响韩国成年人遗传肥胖风险.
- 使用大型队列和全基因组关联研究进行强大的分析.
主要方法:
- 一项前性队列研究,涉及8458名韩国成年人 (40-69岁).
- 基于六个与肥胖相关的SNP计算的遗传风险评分 (GRS).
- 使用食物频率问卷和因素分析确定饮食模式.
主要成果:
- 精制碳水化合物饮食模式显示,在最高GRS组中,与肥胖有显著的反向关联 (OR:0.801,P=0.0251).
- 然而,精制碳水化合物摄入量最高和GRS摄入量最高的人患肥胖率增加 (OR: 1.288,P=0.0251).
结论:
- 减少精制碳水化合物消费可能对韩国成年人有很高的遗传易感性对肥胖有益.
- 饮食修改可能会抵消对肥胖的遗传倾向.
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