多模式人工智能用于机遇性查,分期和进展风险分层的脂肪性肝病
Yuan Gao1,2, Chunli Li3, Wanxing Chang1,2
1DAMO Academy, Alibaba Group, Hangzhou, China.
Nature communications
|February 11, 2026
概括
一个人工智能模型使用CT扫描准确检测脂肪性肝病 (脂肪性肝病) 和纤维化. 将这种工具整合到临床实践中可以识别更多的风险患者,以便进行早期干预和管理.
科学领域:
- 放射学 放射学是一门学科.
- 人工智能的人工智能
- 肝病学 肝病学是一种肝病学.
背景情况:
- 脂肪性肝病 (脂肪性肝病) 是一个日益严重的全球健康问题.
- 非对比式计算机断层扫描 (CT) 扫描用于机会性检测,但缺乏强大的分期和风险评估能力.
- 精确的分期和风险分层对于管理脂肪性肝病和预防进展至关重要.
研究的目的:
- 开发和验证一种多式人工智能模型,用于检测和评估脂肪性肝病和纤维化症的严重程度.
- 评估模型对临床风险查和患者管理的影响.
- 展示AI模型在脂肪性肝病的早期检测和改善结果方面的潜力.
主要方法:
- 一个多式人工智能模型被训练在一个庞大的数据集上 histopathologically 和放射学确认的病例 (n=968 和 n=1103,分别).
- 该模型根据组织学 (n=660) 和MRI-PDFF (n=375) 黄金标准进行了验证.
- 人工智能模型被整合到标准的临床途径中,并在患者队列 (n=1192) 上进行了回顾性评估.
- 考克斯的比例危险模型被用来评估AI识别的风险类别与肝硬化发病率之间的关联.
主要成果:
- 人工智能模型在检测轻度至重度肥胖症 (AUC:0.904-0.929) 和临床显著纤维化 (AUC:0.824-0.888) 中表现出高准确度.
- 将人工智能模型整合到临床实践中,发现36%的患者有纤维化进展的风险.
- 由人工智能模型识别的中高风险患者的肝硬化发病率显著更高 (危险比:5.54).
结论:
- 多式人工智能模型对精确检测和稳态性肝病和纤维化病的分期使用非对比CT显著有前途.
- 这种人工智能工具的临床整合增强了初级风险查,可以更早地识别需要干预的患者.
- 人工智能模型有助于主动管理脂肪性肝病,可能减少肝硬化等晚期并发症的发生率.
更多相关视频
06:26Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis
Published on: July 18, 2025
904
09:27Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish
Published on: April 1, 2021
4.0K
相关概念视频
Diseases of the Liver and Gallbladder
2.0K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
2.0K
Sensory Modalities
4.0K
Sensation typically is the process by which the sensory receptors and sense organs detect stimuli from the internal and external environment and transmit this information to the central nervous system for processing.
General senses refer to the broad category of sensory information detected by receptors in the body and can be further grouped into somatic and visceral senses. Somatic sensations include touch, pressure, temperature, and pain and are essential for navigating our environment and...
General senses refer to the broad category of sensory information detected by receptors in the body and can be further grouped into somatic and visceral senses. Somatic sensations include touch, pressure, temperature, and pain and are essential for navigating our environment and...
4.0K
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
208
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
208
Relative Risk
2.2K
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.2K
Tumor Progression
7.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.5K
Factors Affecting the Risk of Infection
13.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.8K
