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传染MPXV从火脚绳松鼠到灰的蜜蜂
Carme Riutord-Fe1,2, Jasmin Schlotterbeck1, Lorenzo Lagostina1
1Department of Ecology and Emergence of Zoonotic Diseases, Helmholtz Institute for One Health (HIOH), Helmholtz Centre for Infection Research (HZI), Greifswald, Germany.
Nature
|February 11, 2026
概括
在非洲灰熊蜂中出现的麻疹病毒 (MPXV) 爆发与受感染的火脚绳松鼠有关. 这项研究提供了罕见的直接物种间传播的证据,突出了从松鼠到人类的潜在动物感染风险.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 流行病学 流行病学
- 野生动物疾病生态学 野生动物疾病生态学
背景情况:
- 马普克斯病毒 (MPXV) 正在西非和中非出现,非洲动物被怀疑是蓄水池.
- 从动物直接传播MPXV到非人类灵长类动物,比如灰熊蜂,此前还没有确立.
- 了解MPXV传播动态对于受影响地区的公共卫生至关重要.
研究的目的:
- 调查在科特迪瓦的一个野生灰尘曼加贝群体中爆发麻病毒 (MPXV) 疫情的来源.
- 为了确定负责将MPXV传播给mangabey群体的特定动物物种.
- 提供MPXV在自然环境中直接跨物种传播的证据.
主要方法:
- 从受感染的灰熊蜂和潜在的动物水库中对MPXV进行基因组测序.
- 对野生动物尸体和环境样本进行MPXV存在的分析.
- 使用DNA元编码的便样本的饮食分析.
- 审查历史视频记录,以评估物种之间过去的相互作用.
主要成果:
- 一个MPXV疫情发生在一个灰的mangabey群体中,导致婴儿死亡率.
- 一个几乎相同的MPXV基因组被确定在一个死去的火脚绳索松鼠发现附近的mangabey领土.
- 饮食分析证实,虫食用的是火脚的绳索松鼠,其中一个阳性MPXV样本含有松鼠DNA.
- 历史上的视频证据显示,蜂吃同一种松鼠物种.
结论:
- 火脚绳松鼠被确定为MPXV疫情的来源.
- 这项研究提供了MPXV从松鼠向非人类灵长类动物的跨物种传播的罕见,直接证据.
- 这些发现凸显了MPXV通过狩猎和食用松鼠和非人类灵长类动物传染给人类的潜在动物感染风险.
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