丝纤维素涂层的复星固体脂质纳米颗粒用于糖尿病伤口愈合
Subhasri Bogadi1, Mohamed Rahamathulla2, Veera Venkata Satyanarayana Reddy Karri3
1Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, Tamil Nadu, 643001, India.
Scientific reports
|February 11, 2026
概括
带有丝纤维素涂层的复星纳米颗粒通过改善复星的稳定性和输送来增强糖尿病伤口愈合. 这些纳米颗粒显示出显著的抗氧化,抗菌和抗炎作用,加速伤口关闭.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 伤口治愈研究研究 伤口治愈研究
背景情况:
- 糖尿病伤口由于延迟愈合和炎症而存在重大临床挑战.
- 复星提供治疗益处,但由于溶解性和稳定性不佳而受到影响.
- 需要新的输送系统来提高白醇在糖尿病伤口治疗中的疗效.
研究的目的:
- 开发带有丝纤维素涂层的复星固体脂质纳米颗粒 (SF-RSLNs) 来增强复星的输送.
- 为了优化SF-RSLN的制造,并描述它们的特性.
- 评估SF-RSLNs在加速糖尿病伤口愈合方面的治疗效果.
主要方法:
- 使用微乳液技术制造的SF-RSLN,通过Box-Behnken设计进行优化.
- 描述包括粒子大小,泽塔潜力,捕获效率,药物负载,FTIR,SEM和DLS.
- 在体外研究中评估了细胞毒性,抗氧化剂,抗菌,抗炎和血液相容性.
主要成果:
- 优化的SF-RSLN显示了有利的粒子大小 (222.1 nm),泽塔电位 (-32 mV),高捕获率 (85.7%) 和负载 (10.2%).
- SF-RSLNs表现出持续释放,强烈的抗氧化活性 (85% DPPH 清除) 和显著的伤口关闭 (90% 在 48h).
- 观察到增强了对S. aureus和E. coli的抗菌作用,降低了TNF-α,增加了IL-10和良好的血液兼容性.
结论:
- SF-RSLNs有效地提高了白醇的稳定性和受控释放.
- 开发的纳米粒子表现出糖尿病伤口愈合的多功能治疗特性.
- SF-RSLNs代表了一种有前途的纳米载体,可以加速糖尿病伤口的修复.
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