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BUB1促进干细胞的类似性质,并作为肺癌的诊断生物标志物

Mulin Liu¹, Siqi Zhu¹, Qin Zheng²

¹Department of Clinical Laboratory, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, Liaoning, China.

Scientific reports

|February 11, 2026

概括

这项研究确定BUB1是肺癌的关键干细胞生物标志物,对诊断和预后至关重要. 抑制BUB1可以克服由癌症干细胞 (CSCs) 驱动的治疗耐药性.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物标志物发现发现

背景情况:

癌症干细胞 (CSCs) 在肺癌中驱动治疗耐药性和低生存率.
识别与茎相关的生物标志物对于改善肺癌患者的治疗结果至关重要.

研究的目的:

在肺癌中识别关键的茎性相关基因.
评估BUB1作为诊断和预后生物标志物.
探索BUB1在CSC中的作用,并确定潜在的治疗点.

主要方法:

权重基因共同表达网络分析 (WGCNA) 和Venn分析.
在肺癌组织中分析mRNA干度指数 (mRNAsi) 和BUB1表达.
接收器操作特征 (ROC) 分析用于诊断价值.
瘤球形成试验和机械学研究的西方抹杀.
分子对接用于药物向.

主要成果:

BUB1被确定为与茎相关的模块中的枢纽基因,在肺癌中显著增加表达和mRNAsi.
BUB1显示了高的诊断准确性 (AUC,灵敏度,特异性) 并预测了LUAD患者的低生存率.
通过IL-17通路的失活,BUB1的淘汰减少了茎状特征和茎状标志物.
奎尔塞丁,克里托莱平和埃托波西德被确定为潜在的BUB1向药物.

结论:

BUB1是肺癌的宝贵诊断生物标志物,也是LUAD的独立预后指标.
针对BUB1,可能与已识别的药物,提供了一个有希望的策略,以克服CSC驱动的治疗耐药性.

关键词:

一个BUB1一个BUB1 生物标志物生物标志物肺癌是一种肺癌.一个的子.

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