听觉刺激在引起意识受损的重症患者的反应性方面最有效
Wolmet E Haksteen1, Lis N K Zandbergen2, Nick Eleveld3
1Department of Intensive Care, Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. w.e.haksteen@amsterdamumc.nl.
Neurocritical care
|February 11, 2026
概括
听觉刺激是最有效的引起电脑电图 (EEG) 反应在重症监护室 (ICU) 患者的意识受损. 标准化测试提高了检测确定性,尽管反应性无法预测结果.
科学领域:
- 神经科学是一个神经科学.
- 关键护理医学 关键护理医学
- 临床神经生理学 临床神经生理学
背景情况:
- 脑电图 (EEG) 反应性是重症监护室 (ICU) 患者功能结果的潜在预测因素.
- 不同刺激在引起脑电图反应的有效性需要进一步的研究在有意识障碍的患者.
- 了解最佳刺激类型对于在重症监护中进行准确的预后评估至关重要.
研究的目的:
- 确定最有效的刺激,以引起脑电图反应,在ICU患者的意识受损.
- 调查EEG反应性与医院生存和功能结果之间的关联.
- 为了比较标准化与随机刺激的有效性,用于EEG反应性测试.
主要方法:
- 成年ICU患者的意识受损,经过EEG反应性测试使用听觉,视觉,触觉和有害刺激.
- 三名盲目评定者评估了EEG反应性,使用Fleiss' kappa评估了评定者之间的可靠性.
- 使用后勤回归分析来检查反应性和临床结果之间的关联.
主要成果:
- 听觉刺激 (鼓掌,呼叫) 在引起EEG反应方面最有效 (57%的反应性刺激).
- 脑电图反应在30.6%的患者中存在,与住院生存或6个月功能结果无关.
- 与随机刺激相比,标准化测试显著提高了评级人员在检测反应性方面的确定性 (88.2%与41.8%,p=0.002).
结论:
- 听觉刺激在引起脑电图反应性方面优越,在有意识障碍的重症患者中.
- 经测试的EEG反应性与医院生存或功能结果没有相关性.
- 标准化的刺激应用提高了在ICU环境下EEG反应性评估的可靠性.
相关概念视频
Radical Reactivity: Steric Effects
2.5K
The presence of electron-donating, electron-withdrawing, or conjugating groups adjacent to a radical center, imparts electronic stabilization to the radicals. Examples of such electronically-stabilized radicals are triphenylmethyl, tetramethylpiperidine‐N‐oxide, and 2,2‐diphenyl‐1‐picrylhydrazyl. These radicals are remarkably stable and are known as persistent radicals. Some of the persistent radicals can even be isolated and purified.
Along with electronic...
Along with electronic...
2.5K
Radical Reactivity: Concentration Effects
1.9K
In a radical reaction, the concentration of starting materials governs the selectivity of a radical. For example, the reaction between an alkyl halide and an alkene, in the presence of tin hydride and AIBN, begins with the generation of a tin radical. The generated radical then abstracts halogen from the alkyl halide, producing an alkyl radical. This alkyl radical can either react with tin hydride, yielding an alkane, or add to an alkene, generating a nitrile-stabilized radical, eventually...
1.9K
Pharmacodynamics in Geriatric Patients: Effects of Age
241
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
241
Understanding Consciousness
2.2K
Consciousness can be defined as the state of being aware of and able to think about one's existence, sensations, and surroundings. It encompasses two major components: awareness and arousal. Awareness pertains to the recognition of environmental stimuli and internal states. At the same time, arousal refers to the physiological readiness to engage with these stimuli, which varies significantly between states like sleep and wakefulness.
Sleep, a crucial state, is characterized by reduced...
Sleep, a crucial state, is characterized by reduced...
2.2K
The Auditory Ossicles
3.2K
The auditory ossicles of the middle ear transmit sounds from the air as vibrations to the fluid-filled cochlea. The auditory ossicles consist of two malleus (hammer) bones, two incus (anvil) bones, and two stapes (stirrups), one on each side. These bones develop during the fetal stage and are the ones to ossify first. They are fully mature at birth and do not grow afterward.
The aptly named stapes look very much like a stirrup. The three ossicles are unique to mammals, and each plays a role in...
The aptly named stapes look very much like a stirrup. The three ossicles are unique to mammals, and each plays a role in...
3.2K
Critical Region, Critical Values and Significance Level
13.4K
The critical region, critical value, and significance level are interdependent concepts crucial in hypothesis testing.
In hypothesis testing, a sample statistic is converted to a test statistic using z, t, or chi-square distribution. A critical region is an area under the curve in probability distributions demarcated by the critical value. When the test statistic falls in this region, it suggests that the null hypothesis must be rejected. As this region contains all those values of the...
In hypothesis testing, a sample statistic is converted to a test statistic using z, t, or chi-square distribution. A critical region is an area under the curve in probability distributions demarcated by the critical value. When the test statistic falls in this region, it suggests that the null hypothesis must be rejected. As this region contains all those values of the...
13.4K


