与替代疗法相关的心血管和前列腺癌风险 - - 41个随机对照试验的系统审查和元分析
Carlos A García-Becerra1, Maria I Arias-Gallardo2, Jesús E Juárez-García3
1Research Department, Urovallarta Medical Center, Puerto Vallarta, México. agbcarlos94@gmail.com.
International journal of impotence research
|February 11, 2026
概括
在随机对照试验中,疗法 (TTh) 没有显著增加主要不良心血管事件或前列腺癌事件. 这一系统性审查支持TTh.
科学领域:
- 内分泌学和泌尿病学 在内分泌学和泌尿病学
- 心血管医学 心血管医学
- 在瘤学瘤学.
背景情况:
- 疗法 (TTh) 是一种常见的治疗晚期出现的阴性双胞胎症.
- 有关TTh与主要不良心血管事件 (MACE) 和前列腺癌事件 (PCaE) 的关联存在担忧.
- 需要有力的证据来澄清这些风险.
研究的目的:
- 系统地审查和元分析TTh的随机对照试验 (RCT).
- 评估与TTh相关的MACE,PCaE和临床显著前列腺癌 (CsPcE) 的风险.
- 评估TTh.Th.的短期和中期安全概况.
主要方法:
- 按照PRISMA指南在PROSPERO (CRD42024603054) 中注册的系统审查和元分析.
- 在PubMed,ClinicalTrials.gov和Cochrane Central中搜索相关的RCT.
- 包括41个RCT (11,161名参与者);使用适当的统计模型估计了聚合几率比率 (OR).
主要成果:
- TTh与MACE增加没有显著关联 (OR 0.83;95% CI:0.52-1.32).
- TTh与PCaE (OR 0.88;95% CI:0.52-1.51) 或CsPcE (OR 1.13;95% CI:0.39-3.26) 没有显著的关联.
- 伴随性疾病影响了MACE结果的异质性;仍需要长期数据.
结论:
- 目前来自RCT的证据支持丸激素治疗的短期到中期安全性.
- TTh似乎不会增加MACE或前列腺癌事件的风险.
- 需要进行进一步的长期研究,以充分确定TTh的安全性.
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