莱昂氨酸通过小鼠肝脏PI3K/AKT/mTOR通路减轻缺血-再输液损伤
Pengru Wang1,2, Xin Hu1,2, Haiyan Pu1,2
1Metabolic Hepatobiliary and Pancreatic Diseases Key Laboratory of Luzhou City, Academician (Expert) Workstation of Sichuan Province, the Affiliated Hospital, Southwest Medical University, Luzhou, China.
Phytotherapy research : PTR
|February 11, 2026
概括
莱昂林 (SCM-198) 有效地保护肝脏免受缺血-再输液 (I/R) 损伤. 这种化合物减少炎症,亡和细胞循环停止,为肝脏保护提供了一个有前途的治疗选择.
科学领域:
- 药理学 药理学是指药理学的学科.
- 肝病学 肝病学是一种肝病学.
- 分子生物学分子生物学
背景情况:
- 肝缺血-再输血 (I/R) 损伤是肝移植,切除和休克期间的重大临床挑战.
- 目前肝脏I/R损伤的药物治疗有限,需要新的治疗策略.
研究的目的:
- 研究莱昂林 (SCM-198) 对肝脏I/R损伤的肝脏保护作用.
- 阐明SCM-198保护作用的基础分子机制.
主要方法:
- 在体内研究使用小鼠模型的肝脏I / R损伤与SCM-198预治疗.
- 在体外研究中使用AML12细胞暴露于低氧/低氧化 (H/R) 和SCM-198预处理.
- 用各种生化和组织学分析评估损伤,炎症,亡和细胞循环进展.
- 通过网络药理学,分子对接和分子动力学模拟来探索分子目标.
主要成果:
- SCM-198显著降低了肝脏亡,血清中氨酸酶水平和促炎性细胞因子表达.
- 该化合物降低了白细胞透,抑制了亡,并在I/R受伤的肝脏中恢复了cyclin D1/cyclin E1水平.
- 在体外,SCM-198改善了细胞活力,降低了氧化应激,并在H/R治疗的AML12细胞中表现出抗亡作用.
- 网络分析和模拟确定了酸-3-激酶 (PI3K) 作为一个关键目标,SCM-198促进PI3K/AKT/mTOR通路的激活.
结论:
- 莱昂林 (SCM-198) 显示出对I/R损伤有显著的肝保护作用.
- SCM-198通过抑制炎症,细胞亡和细胞循环停止来减轻肝损伤.
- 保护机制涉及PI3K/AKT/mTOR信号通路的激活.
- SCM-198是治疗肝脏I/R损伤的有希望的候选药物.
相关概念视频
PI3K/mTOR/AKT Signaling Pathway
5.7K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
5.7K
Transcription Attenuation in Prokaryotes
18.6K
Transcriptional attenuation occurs when RNA transcription is prematurely terminated due to the formation of a terminator mRNA hairpin structure. Bacteria use these hairpins to regulate the transcription process and control the synthesis of several amino acids including histidine, lysine, threonine, and phenylalanine. Transcription attenuation takes place in the non-coding regions of mRNA.
There are several different mechanisms used to attenuate transcription. In ribosome mediated...
There are several different mechanisms used to attenuate transcription. In ribosome mediated...
18.6K
mTOR Signaling and Cancer Progression
4.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
4.9K
C4 Pathway and CAM
49.3K
Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
C4 Pathway
The C4 pathway is used by plants such as...
C4 Pathway
The C4 pathway is used by plants such as...
49.3K
Other Glycolytic Pathways
993
The pentose phosphate pathway (PPP) operates in parallel with glycolysis, facilitating the metabolism of both pentoses and glucose. This pathway consists of two distinct phases: the oxidative and non-oxidative phases. While it does not directly generate ATP, the intermediates formed during the process can integrate into glycolysis, contributing to cellular energy metabolism when required.Oxidative Phase: NADPH ProductionThe oxidative phase of the pentose phosphate pathway is primarily...
993
Respiration Pathways
798
Cellular respiration is a fundamental metabolic process that enables organisms to generate energy from organic molecules. One of its central pathways is the tricarboxylic acid (TCA) cycle, also known as the Krebs cycle, which plays a crucial role in energy production and biosynthetic processes.Conversion of Pyruvate to Acetyl-CoAThe pyruvate generated from glycolysis undergoes oxidative decarboxylation by the pyruvate dehydrogenase complex, producing acetyl-CoA, one molecule of NADH, and one...
798


