酸盐混合物暴露与绝经后妇女的氧化失衡有关:使用WQS,qgcomp和BKMR进行的横截面研究
Hao Sun1, Mengmeng Wang2, Yuwen Xu1
1Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao, 266071, China.
European journal of medical research
|February 12, 2026
概括
暴露于甲酸盐混合物,特别是来自单-n-丁甲酸盐 (MBP) 和单-2-乙基甲酸盐 (MEHP),与绝经后妇女的氧化失衡有关. 这表明由于环境污染物增加了氧化应激.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 内分泌学 在内分泌学.
背景情况:
- 酸盐是内分泌干扰物和常见的环境污染物.
- 绝经后的女性可能更容易受到氧化应激,因为雌激素的抗氧化作用减少了.
- 甲酸盐混合物暴露对这一人口群体的氧化还原平衡的影响尚不清楚.
研究的目的:
- 在绝经后的妇女中检查尿甲酸代谢物和氧化平衡评分 (OBS) 之间的关联.
- 在复杂的暴露混合物中识别关键的甲酸盐贡献者.
- 评估甲酸盐混合物对全身氧化平衡的影响.
主要方法:
- 国家健康和营养检查调查 (NHANES) 数据 (2005-2018) 的横截面分析.
- 使用HPLC-ESI-MS/MS.对5种尿甲酸代谢物的量化.
- 应用多种统计模型,包括WQS回归,量子g计算和BKMR来分析混合物效应.
主要成果:
- 尿液中单-n-丁甲酸盐 (MBP) 和单-2-乙基甲酸盐 (MEHP) 的水平升高与较低的OBS有关,这表明氧化应激增加.
- 混合模型证实了整体甲酸盐暴露和氧化平衡之间的显著反向关系.
- 确定MBP和MEHP是造成有害氧化作用的主要甲酸盐贡献者.
结论:
- 酸盐混合物暴露,特别是涉及MBP和MEHP,与绝经后妇女的氧化失衡有关.
- 这些发现强调了在环境健康评估中考虑化学混合物的必要性.
- 建议进行进一步的纵向研究,以确定因果关系并探索机制.
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