相关实验视频
Updated: Feb 13, 2026

04:43
Detection of Lung Tumor Progression in Mice by Ultrasound Imaging
Published on: February 27, 2020
7.4K
单核多组学划分了与肺腺癌瘤瘤进展相关的独特表观遗传程序
Yeji Kim1,2, Huiram Kang1,2, Yongki Hwang3,4
1Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Clinical epigenetics
|February 12, 2026
概括
这项研究调查了肺腺癌 (LUAD) 的起源,揭示了患者特定的瘤演变. 一个LUAD病例显示了逐渐的AT2细胞过渡,而另一个则显示了ROS1融合驱动的信号传递,突出了各种分子通路.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 分子生物学分子生物学
背景情况:
- 肺腺癌 (LUAD) 是一种异质性癌症,可能起源于2型 (AT2) 膜细胞.
- 了解AT2细胞转化和LUAD异质性对于向疗法至关重要.
研究的目的:
- 为了研究在LUAD中AT2细胞转化的调节机制.
- 使用多原子单核分析探索内异质性的分子驱动因素.
主要方法:
- 在LUAD瘤样本上进行了结合单核RNA测序 (snRNA-seq) 和snATAC-seq的多组测定.
- 集成的snRNA-seq和snATAC-seq数据,以识别差异可访问的染色体区域和相关基因.
- 利用轨迹推断来模型细胞状态转换和转录因子驱动的重塑.
主要成果:
- 分析了两名患者的LUAD:一个患有TP53突变,另一个患有ROS1融合.
- 在 snRNA-seq 和 snATAC-seq 中,分辨出了不同的细胞群和调控元素.
- 一个案例显示了逐渐的AT2到瘤细胞的过渡与表观基因组重塑;ROS1融合案例显示PI3K/AKT/mTOR通路激活.
结论:
- LUAD的演变遵循患者特定的模式,包括渐进的AT2细胞转化或瘤性融合驱动信号.
- 转录和表观遗传程序分歧,导致LUAD患者间异质性.
- 这项研究提供了关于LUAD起源和潜在治疗策略异质性的见解.
相关概念视频
Tumor Progression
7.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.5K
Epigenetic Regulation
33.9K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.9K
Epigenetic Regulation
3.9K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.9K
The Nucleus
105.1K
The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
105.1K
The Nucleus
7.7K
The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
7.7K
Lung Capacity
56.4K
The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
56.4K

