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相关概念视频

Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

24.9K
Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
24.9K
What is Gene Expression?01:42

What is Gene Expression?

197.1K
Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
197.1K
What is Gene Expression?01:36

What is Gene Expression?

11.6K
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then...
11.6K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

16.6K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.6K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

5.6K
5.6K
mRNA Stability and Gene Expression02:51

mRNA Stability and Gene Expression

6.7K
The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
Cis-acting Elements involved in mRNA stability
6.7K

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相关实验视频

Updated: Feb 13, 2026

Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps
11:52

Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps

Published on: February 9, 2017

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预TSA:对时间和空间基因表达模式的计算高效建模.

Haotian Zhuang1, Zhicheng Ji2

  • 1Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, USA.

Genome biology
|February 12, 2026
PubMed
概括
此摘要是机器生成的。

我们开发了PreTSA,这是一种高效的计算方法,用于分析大型单细胞和空间转录组学数据集中的基因表达模式. PreTSA与现有的方法相匹配.

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Laser-Capture Microdissection RNA-Sequencing for Spatial and Temporal Tissue-Specific Gene Expression Analysis in Plants
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Laser-Capture Microdissection RNA-Sequencing for Spatial and Temporal Tissue-Specific Gene Expression Analysis in Plants

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Using the Gene Pulser MXcell Electroporation System to Transfect Primary Cells with High Efficiency
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Using the Gene Pulser MXcell Electroporation System to Transfect Primary Cells with High Efficiency

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相关实验视频

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Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps
11:52

Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps

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Laser-Capture Microdissection RNA-Sequencing for Spatial and Temporal Tissue-Specific Gene Expression Analysis in Plants
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Laser-Capture Microdissection RNA-Sequencing for Spatial and Temporal Tissue-Specific Gene Expression Analysis in Plants

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Using the Gene Pulser MXcell Electroporation System to Transfect Primary Cells with High Efficiency
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Using the Gene Pulser MXcell Electroporation System to Transfect Primary Cells with High Efficiency

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科学领域:

  • 计算生物学是一种计算生物学.
  • 基因组学就是基因组学.
  • 生物信息学是一种生物信息学.

背景情况:

  • 对基因表达模式进行大规模单细胞和空间转录组学数据的分析是计算要求很高的.
  • 现有的方法与现代转录基因数据集的规模扎,限制了生物洞察力.

研究的目的:

  • 介绍PreTSA,一种计算效率高的方法,用于建模时间和空间基因表达模式.
  • 为了证明PreTSA对大规模单细胞和空间转录组学数据的适用性,包括数百万个细胞.

主要方法:

  • 开发PreTSA,一种新的计算方法.
  • 在不同大小的单细胞和空间转录组学数据集中应用PreTSA.

主要成果:

  • 与最先进的方法相比,PreTSA显著减少了计算时间.
  • 在建模基因表达模式方面,PreTSA取得了与现有方法相似的结果.
  • 对于包含数百万个单元的数据集,PreTSA证明了它们的可扩展性.

结论:

  • PreTSA提供了一个计算效率高的解决方案,用于分析大规模的转录学数据.
  • 这种方法使得在前所未有的大型数据集中研究基因表达模式成为可能.
  • 从单细胞和空间转录组学中,PreTSA促进了更深入的生物学见解.