日本福岛县与传染病相关的急性脑炎/脑病变:一项流行病学研究
Mitsuaki Hosoya1,2, Yohei Kume1, Sakurako Norito1
1From the Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan.
The Pediatric infectious disease journal
|February 12, 2026
概括
福岛的急性脑炎发病率是每年每10万名幼儿中有15.2人. 聚合酶连锁反应 (PCR) 测试显著改善了相关传染病原体的识别.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 在日本,关于急性脑炎/脑病变发生率和致病原体的数据有限.
- 以前的流行病学调查还没有完全阐明疾病负担和病因学.
研究的目的:
- 确定福岛县急性脑炎/脑病变的流行病学特征.
- 用先进的诊断方法识别相关的传染病和病原体.
主要方法:
- 从2014年到2024年,福岛县的16个儿科机构进行了前性活跃调查.
- 聚合酶链反应 (PCR) 测试与福岛医科大学医院的传统诊断一起使用.
- 收集了患者人口统计,临床表现和已识别的病原体的数据.
主要成果:
- 在11年内报告了106例与感染相关的急性脑炎/脑病变,平均每年9.6例.
- 年均发病率估计为每10万5岁以下儿童中15.2例.
- 在59.4%的病例中发现了病原体,其中人类疹病毒-6/7和流感病毒是最常见的. 在住院病例中,PCR测试将病原体识别率提高到76.0%.
结论:
- 在福岛,5岁以下儿童中,急性脑炎/脑病变的年均发病率为每10万人中15.2例.
- 综合PCR分析可以提高病原体检测,这对于理解和管理急性脑炎/脑病变至关重要.
- 调查结果强调需要持续监测和先进的诊断方法.
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