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在老年患者中,对triaxone相关的肝功能障碍进行风险因素分析
Tomohiko Tagashira1, Ryoya Odawara2, Naohito Suga2
1Department of Pharmacy, Innoshima-Ishikai Hospital, 1962 Nakanosho-cho, Innoshima, Onomichi-shi, Hiroshima, Japan. bcxpc0252000@yahoo.co.jp.
Journal of pharmaceutical health care and sciences
|February 12, 2026
概括
基线阿氨基转移酶 (ALT) 和C-反应蛋白 (CRP) 水平升高,增加了老年人患 (CTRX) 相关肝功能障碍的风险. 对这种人群来说,监测肝功能至关重要.
科学领域:
- 药理学 药理学是指药理学的学科.
- 肝病学 肝病学是一种肝病学.
- 老年病的医生 老年病的医生
背景情况:
- 关于老年患者的triaxone (CTRX) 诱导的肝损伤的数据有限.
- 这项研究旨在确定65岁及以上个体中CTRX相关肝功能障碍的危险因素.
研究的目的:
- 在65岁及以上的患者中研究氏相关性肝功能障碍的危险因素.
- 为已识别的风险因素建立最佳切割值.
主要方法:
- 对105名接受CTRX.X治疗的65岁以上住院患者的回顾性图表审查.
- 用单变量和多变量逻辑回归分析来确定独立的风险因素.
- 接收器操作特征 (ROC) 曲线分析确定了氨酸转移酶 (ALT) 和C反应蛋白 (CRP) 的最佳切断值.
主要成果:
- 升高的基线ALT (≥11 U/L) 和CRP (≥5.9 mg/dL) 在单变分析中与肝功能障碍显著相关.
- 多变量分析证实ALT (OR 1.14) 和CRP (OR 1.07) 是独立的风险因素.
- 患有高ALT和CRP的患者表现出50%的肝功能障碍发病率,明显高于其他组 (p<0.001).
结论:
- 基线ALT和CRP水平升高与老年人中CTRX诱导的肝功能障碍风险增加有关.
- 该研究建议在这种人口群中在CTRX的使用期间和之后仔细监测肝功能.
- 识别ALT或CRP升高的患者可以帮助预测和潜在地预防CTRX相关的肝损伤.
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