基线炎症标志物作为与跑步有关的伤害的预测者:一年前景4HAIE队列研究
Lukas Cipryan1, Jiri Skypala1, Martina Litschmannova2
1Department of Human Movement Studies & Human Motion Diagnostic Centre, The University of Ostrava, Ostrava, Czech Republic.
Scandinavian journal of medicine & science in sports
|February 12, 2026
概括
基线瘤坏死因子α (TNF-α) 和介素-1受体对抗剂 (IL-1RA) 与与跑步相关的损伤 (RRI) 风险有关. 然而,仅仅这些炎症标志物不足以预测个体的RRI发生.
科学领域:
- 运动医学 运动医学
- 生物化学 生物化学
- 运动生理学 运动生理学
背景情况:
- 与跑步相关的伤害 (RRI) 是常见的,炎症过程可能会影响易感性.
- 基线炎症生物标志物对健康个体RRI发生的预测价值尚未得到充分确立.
研究的目的:
- 调查基线生物化学炎症标志物是否能在一年内预测健康个体的RRI发生.
- 评估炎症标志物的作用与训练,生理和伤害史在RRI预测中的作用.
主要方法:
- 一项前性研究,对1315名健康人群 (跑步者和对照人群) 进行了12个月的伤害监测.
- 基线血液样本分析炎症标志物;用于分析的多变量逻辑回归.
- 根据年龄,性别,氧气消耗峰值,跑步距离,身体脂肪和之前的肌肉骨创伤进行调整.
主要成果:
- 基线瘤坏死因子α (TNF-α) 是RRI的显著预测因子 (OR每1 pg/mL:1.25).
- 肌肉骨创伤史,每周跑步距离和年龄也预测了RRI.
- 介素-1受体对抗剂 (IL-1RA) 显示出适度的保护性关联 (每10 pg/mL的OR:0.99).
- 预测模型具有有限的区分能力 (AUC = 0.66).
结论:
- 基线TNF-α和IL-1RA与RRI发生有关,这表明炎症有助于受伤易感性.
- 这些炎症标志物不足以作为独立查工具来预测个人RRI.
- 炎症表型是多因素RRI风险的一个组成部分,为潜在的预防策略提供了信息.
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