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Updated: Feb 13, 2026

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells
13:38

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells

Published on: January 18, 2017

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合成和特征的ULK1/2激酶抑制剂,抑制自和Upregulate表达的主要基因相容性复合物I治疗非小细胞肺癌的治疗

Fabiana Izidro A L Layng1, Huiyu Ren1, Nicole A Bakas1

  • 1Center for Therapeutics Discovery, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, United States.

ACS chemical biology
|February 12, 2026
PubMed
概括

新的双重ULK1/2抑制剂SBP-5147和SBP-7501显示出对治疗非小细胞肺癌 (NSCLC) 的前景. 这些化合物具有细胞毒性,抑制自,并提供更好的口服暴露,可能增强免疫疗法反应.

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