杀菌方法对3D打印树脂的材料性能的影响,长时间暴露在细胞培养环境中
Ashlee Liao1, Michael Bennington1, Kevin Dai1
1Carnegie Mellon University, Department of Mechanical Engineering, Pittsburgh, PA, 15213, USA.
Journal of biomechanical engineering
|February 12, 2026
概括
消毒显著影响3D打印的刚性树脂,降低其机械性能. 像Formlabs40A和Asiga DentaGUM这样的弹性树脂在生物医学应用中显示出更大的稳定性.
科学领域:
- 生物材料科学 生物材料科学
- 机械工程 机械工程
- 生物医学工程 生物医学工程
背景情况:
- 低成本的3D打印对于定制生物医学设备和生物混合机器人技术至关重要.
- 消毒和细胞培养对3D打印树脂机械性能的影响尚不清楚.
研究的目的:
- 评估乙醇/紫外线和车灭菌如何影响五种3D打印树脂的机械性能.
- 在生理条件下的酸盐缓冲盐水 (PBS) 中评估材料的稳定性.
主要方法:
- 在三个刚性树脂和两个弹性树脂上进行了拉伸和压力力学测试.
- 在灭菌后测量了弹性模块,最终抗拉强度和断裂时的应变.
主要成果:
- 刚性树脂 (Phrozen AquaGray 8K,Liqcreate Bio-Med Clear) 在消毒后显著降低了拉伸强度和刚度.
- 与其他刚性树脂相比,Asiga DentaGUIDE (刚性) 的机械稳定性更好.
- 弹性树脂 (Asiga DentaGUM,Formlabs40A) 的性能变化很小,尽管后处理影响了变化.
结论:
- 灭菌严重改变了许多3D打印刚性树脂的机械完整性.
- 亚西加DentaGUIDE和Formlabs40A是需要灭菌的生物混合应用的强大候选者.
- 在预期的使用条件下对3D打印树脂特性进行实验验证对于生物医学设备的开发至关重要.
更多相关视频
14:49Direct and Indirect Culture Methods for Studying Biodegradable Implant Materials In Vitro
Published on: April 15, 2022
5.7K
07:08Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood
Published on: September 5, 2017
8.9K
相关概念视频
01:30Methods of Sterilization II: Chemical Methods
9.2K
In healthcare, the chemical method of sterilization uses chemical sterilants to treat surgical instruments and medical supplies to help prevent the transmission of infectious pathogens to patients. Due to heat sensitivity, most medical supplies and equipment should not be exposed to high temperatures. These parts include rubber, plastic, glass, and other similar elements.
Using chemical sterilization rather than heat to clean out equipment is recommended. It eradicates and removes all bacteria,...
Using chemical sterilization rather than heat to clean out equipment is recommended. It eradicates and removes all bacteria,...
9.2K
01:29Methods of Sterilization I: Physical Methods
23.8K
As used in a healthcare facility, sterilization destroys all microorganisms through physical or chemical methods. The physical method includes steam, dry heat, boiling water, and radiation.
Steam sterilization uses non-toxic, low-cost moist heat in the form of saturated steam under pressure, which is fast, microbicidal, and sporicidal, and quickly warms and penetrates fabrics. Autoclaves, or steam sterilizers, expose each item to direct steam contact for a predetermined time at the necessary...
Steam sterilization uses non-toxic, low-cost moist heat in the form of saturated steam under pressure, which is fast, microbicidal, and sporicidal, and quickly warms and penetrates fabrics. Autoclaves, or steam sterilizers, expose each item to direct steam contact for a predetermined time at the necessary...
23.8K
01:30Cleaning, Sterilization, and Disinfection
10.6K
Cleaning, disinfection, and sterilization are the methods that help to break the infection chain and prevent disease.
Cleaning
The cleaning process usually involves using water with detergents or enzymatic cleaner and removing foreign material from objects and surfaces, including organic material such as body fluids or inorganic material like soil. Cleaning is performed before high-level disinfection and sterilization because foreign materials on the cover of the devices interfere with process...
Cleaning
The cleaning process usually involves using water with detergents or enzymatic cleaner and removing foreign material from objects and surfaces, including organic material such as body fluids or inorganic material like soil. Cleaning is performed before high-level disinfection and sterilization because foreign materials on the cover of the devices interfere with process...
10.6K
01:19Impact of Groups on Groups
262
Social psychologists analyze how groups influence one another, shaping social structures and interactions through both cooperation and competition. These dynamics manifest in various ways, ranging from economic partnerships to intergroup conflicts that shape societal structures and perceptions.Cooperation and Competition in Intergroup RelationsIntergroup relationships vary across contexts, sometimes fostering cooperation and mutual benefit while at other times leading to conflict and...
262
01:30Impact
513
Impact occurs when two bodies collide, leading to the application of impulsive forces between them. Analyzing impact mechanics involves considering two colliding particles moving along a line known as the line of impact, which passes through their centers and is perpendicular to the contact plane.
When particles with different initial velocities collide, they induce deformation by applying equal and opposite impulses. At the point of maximum deformation, the particles move together with...
When particles with different initial velocities collide, they induce deformation by applying equal and opposite impulses. At the point of maximum deformation, the particles move together with...
513
01:20Genetic Material
3.8K
Within the human body, a complex and detailed system of trillions of cells works in unison to sustain life. Each cell houses a nucleus, which contains 46 chromosomes divided into 23 pairs. Chromosomes are highly coiled structures made of the genetic material DNA. These chromosomes are essential carriers of genetic information, with half inherited from the mother through her egg and the other half from the father's sperm, combining to create the unique genetic makeup of an individual.
3.8K